Science News – Scientific Sessions 2022

TRANSFORM-HF

Comparative Effectiveness of Torsemide versus Furosemide in Heart Failure: Primary Results of the TRANSFORM-HF Trial
Robert J Mentz | Duke University Hospital, Durham, North Carolina

• TRANSFORM-HF trial data summary slide (PPTX)
• ClinicalTrials ID: NCT03296813
• AHA Press Release: TRANSFORM-HF trial found no difference in effectiveness between 2 common loop diuretics
• Short Video: TRANSFORM-HF Results in under 2 minutes

DCP

Chlorthalidone Compared to Hydrochlorothiazide for the Prevention of Cardiovascular Events in Patients With Hypertension
Areef Ishani | Minneapolis VA Health Care System, Minneapolis, Minnesota

• DCP trial data summary slide (PPTX)
• Clinical Trials ID: NCT02185417
• AHA Press Release: No difference in heart outcomes found in use of two diuretics to treat blood pressure

PROMINENT

A Randomized Trial of Pemafibrate for Triglyceride Reduction in the Prevention of Cardiovascular Disease
Aruna D Pradhan, Brigham and Women's Hospital | Boston, Massachusetts

• PROMINENT Study Data Summary (PPTX)
• PROMINENT: Published in NEJM(link opens in new window)
• Editorial in NEJM
• ClinicalTrials ID: NCT03071692
• AHA Press Release: New medicine reduces triglyceride by 25%, no change in CVD risk in people with Type 2 diabetes

CRISPR ATTR

First-in-Human in vivo CRISPR/Cas9 Editing of the TTR Gene by NTLA-2001 in Patients With Transthyretin Amyloidosis With Cardiomyopathy
Julian D Gillmore | University College of London, London, United Kingdom

• CRISPR-ATTR trial data summary (PPTX)
• AHA Press Release: Novel gene-editing therapy shows promise for patients with transthyretin amyloid cardiomyopathy
• ClinicalTrials ID: NCT04601051
• Original article: NEJM, 2021(link opens in new window)

IRONMAN

A Randomized Trial of Intravenous Ferric Derisomaltose in Heart Failure With Reduced Ejection Fraction
Paul R Kalra | Portsmouth Hospital, University NHS Trust, Portsmouth, United Kingdom

• IRONMAN Study Data Slide (PPTX)
• Simultaneously Published in The Lancet (new window)(link opens in new window)
• ClinicalTrials ID: NCT02642562
• AHA Press Release: Intravenous iron improved long-term outcomes for people with heart failure and iron deficiency

STRESS

Steroids to Reduce Systemic Inflammation After Infant Heart Surgery: The STRESS Trial
Kevin D Hill | Duke Pediatric and Adult Congenital Heart Center, Durham, North Carolina

• STRESS trial data summary slide (PPTX)
• STRESS: Published in NEJM (new window)(link opens in new window)
• ClinicalTrials ID: NCT03229538
• AHA news release: Steroids during surgery may not be helpful for infants having heart bypass

ECMO-CS

Extracorporeal Membrane Oxygenation in the Therapy of Cardiogenic Shock: Primary Results From the Multicenter, Randomized ECMO-CS Trial
Petr Ostadal, Na Homolce Hosp, Prague, Czech Republic

• ECMO-CS trial data summary slide (PPTX)
• ClinicalTrials ID: NCT02301819
• AHA Press release: Early use of ECMO devices did not improve outcomes in people with cardiogenic shock

MB-BP

The Effect of Adapted Mindfulness Training in Participants With Elevated Office Blood Pressure: The Mindfulness-Based Blood Pressure Reduction (MB-BP) Randomized Clinical Trial
Eric B. Loucks | Brown University, Providence, Rhode Island

• ClinicalTrials ID: NCT03859076
• AHA Press Release: Mindfulness shows promise as an effective intervention to lower blood pressure
• Short Video: MB-BP Results in under 3 minutes

EMPA-KIDNEY

Empagliflozin and Cardiovascular Outcomes in Patients With Chronic Kidney Disease: The EMPA-KIDNEY Trial
David Preiss | University of Oxford, Oxford, United Kingdom

• EMPA-KIDNEY trial data summary (PPTX)
• EMPA-KIDNEY Published in NEJM
• ClinicalTrials ID: NCT03594110

PRECISE

Comparison of a Precision Care Strategy With Usual Testing to Guide Management of Stable Patients With Suspected Coronary Artery Disease: The Precise Randomized Trial
Pamela S Douglas | Duke University School of Medicine, Durham, North Carolina

• PRECISE trial data summary (PPTX)
• ClinicalTrials ID: NCT03702244
• AHA press release: Diabetes medicine decreased cardiovascular risk in adults with chronic kidney disease

BEST-CLI

Best Endovascular versus Best Surgical Therapy for Patients With Chronic Limb Threatening Ischemia (BEST-CLI) Trial: Clinical Results
Alik Farber | Boston Medical Center, Boston, Massachusetts

• BEST-CLI trial summary (PPTX)
• Farber Abstract
• Published in NEJM
• AHA News Release: Surgery is best to prevent amputations in certain people with poor leg circulation
• ClinicalTrials ID: NCT02060630

Best Endovascular versus Best Surgical Therapy for Patients With Chronic Limb Threatening Ischemia (BEST-CLI) Trial: Quality of Life Analyses
Matthew T Menard | Brigham and Women's Hospital, Boston, MA

• Menard's Abstract
• BEST-CLI Official website (new window)(link opens in new window)
• AHA News Release: Restored blood flow meant less pain, better quality of life for those with leg artery disease

STRONG HF

Successful Post-Discharge of Heart Failure
Alexandre Mebazaa | University de Paris, Paris, France

• ClinicalTrials ID: NCT03412201
• AHA News Release: Maximizing heart failure meds within 2 weeks reduced risk of hospital readmission, death

RAPID

Self-Administered Etripamil for Termination of Spontaneous Paroxysmal Supraventricular Tachycardia: Primary Analysis From the RAPID Study
James E Ip | Weill Cornell School of Medicine, New York, NY

• RAPID trial data summary (PPTX)
• ClinicalTrials ID: NCT05410860

SPYRAL HTN

Effect of Radiofrequency Renal Denervation on Blood Pressure in the Presence of Antihypertensive Drugs: 6-Month Primary Results From the SPYRAL HTN-ON Med Expansion Randomized Trial
David E Kandzari | Piedmont Heart Institute, Atlanta, GA

• ClinicalTrial ID: NCT04311086