Science News from BCVS 2017
Basic Cardiovascular Sciences Scientific Sessions
July 10 – 13, 2017
Hilton Portland | Portland, Oregon
Jump to one day's coverage: Monday Tuesday Wednesday Thursday
Other important links: Online Program Planner | BCVS 2017 Abstracts (6MB) (PDF) | BCVS 2017 Final Program (PDF) | BCVS 2017 ePosters
Sprr2b Drives Proliferation of Cardiac Fibroblasts by Relieving p53-mediated Cell Cycle Inhibition
Ryan M Burke | University of Rochester, Rochester, NY
- RESULTS: Sprr2b's unique role identified for development of cardiac fibrosis
- Abstract
MANF, A Structurally Unique Redox-Sensitive Chaperone, Restores ER Protein Folding in the Ischemic Heart
Adrian Arrieta | San Diego State University, San Diego, CA
- RESULTS: MANF’s function in reducing ischemic heart damage described.
- Abstract
Loss of Type 9 Adenylyl Cyclase Triggers Reduced Phosphorylation of Hsp20 and Diastolic Dysfunction
Tanya A Baldwin | McGovern Medical School at University of Texas Health Science Center at Houston (UTHealth), Houston, TX
- RESULTS: New roles for AC9 in cardiac function identified.
- Abstract
MicroRNAs Mediate the Hemodynamic Regulation of Endothelium-to-Smooth Muscle Signaling
Jing Zhou | Peking University Health Science Center, Beijing, China
- RESULTS: Identification of SNARE activation process may prove valuable for proliferative vascular diseases.
- Abstract
- Video Interview
Β-Arrestin-Biased Agonism of Β-Adrenergic Receptor Regulates Dicer-mediated MicroRNA Maturation to Promote Cardioprotective Signaling
Jian-Peng Teoh | Augusta University, Augusta, GA
- RESULTS: Novel cardioprotective mechanism described for Β-adrenergic receptor (ΒAR) signaling.
- Abstract
Sildenafil Inhibits Neointimal Hyperplasia After Angioplasty, and Reduces Platelet Aggregation
Han Mo Yang | Seoul National University Hospital, Seoul, Korea, Republic of
- RESULTS: Future applications for sildenafil results may reduce drug-eluting stent complications.
- Abstract
- AHA Press Release: Stent coated with an erectile dysfunction drug may help prevent blood clots and artery narrowing (new window)(link opens in new window)
Cardiomyocyte CaMKII Mediates Expression of Pro-inflammatory Chemokines and Cytokines, Macrophage Infiltration and Cardiac Remodeling in Response to Pressure
Takeshi Suetomi | Department of Pharmacology, University of California, San Diego, School of Medicine, La Jolla, CA
- RESULTS: CMKII's role in inflammatory response, fibrosis, and heart failure.
- Abstract
Restoration of Impaired Diastolic Function in Hypertrophic Cardiomyopathy Induced Pluripotent Stem Cell-derived Cardiomyocytes by Re-balancing the Calcium
Haodi Wu | Stanford University, Stanford, CA
- RESULTS: Induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) demonstrate cellular mechanism for diastolic dysfunction.
- Abstract
Chromatin Organization in Diseased and Healthy Mouse Heart
Chukwuemeka George Anene Nzelu | National University of Singapore, Singapore, Singapore
- RESULTS: 3-D chromatin structure offers first clues to genome-wide chromatin interactions, genomic compartments, and cardiac-specific gene expression.
- Abstract
CTRP9 Regulates the Fate of Implanted Mesenchymal Stem Cells and Mobilizes Their Protective Effects Against Ischemic Heart Injury via Multiple Novel Signaling
Wenjun Yan | Thomas Jefferson University, Philadelphia, PA
- RESULTS: CTRP9 is key to a healthy microenvironment; stem cell research in myocardial infarction may benefit from this finding.
- Abstract
Tracking of CD16 Monocytes Following Delivery Into the Ischemic Limb - a Bench to Bedside Study
Ashish S Patel | King's College London, London, United Kingdom
- RESULTS: First-in-man study finds CD16 monocytes viable in ischemic tissue, suggesting a potential future therapeutic option for patients with critical limb ischemia.
- Abstract
Myocardial Hypertrophy and Circulating RNAs
Ravi V Shah | Massachusetts General Hospital, Boston, MA
- RESULTS: Circulating miRNAs may provide molecular protection in the progression of myocardial hypertrophy to heart failure.
- Abstract
Searching Genetic Modifiers For bag3-based Cardiomyopathy Using Adult Zebrafish Models
Yonghe Ding | Mayo Clinic, Rochester, MN
- RESULTS: Forward mutagenesis screening strategy may help to identify genetic modifiers for cardiomyopathy.
- Abstract
Sphingosine-1-Phosphate and RhoA Signaling Regulate Dynamin-Related Protein 1 and Cardiac Mitochondrial Fission
Cameron S Brand | Univ of California San Diego, La Jolla, CA
- RESULTS: Mitochondrial fission suggests new cardioprotective pathway.
- Abstract
Selected Science from Wednesday, July 12
Heard at BCVS 2017: Oxidized Lipids in Pulmonary HTN - an Early Career view of the "Next Best Thing in CV Research"
Jop van Berlo, MD, PhD interviews Gregoire Ruffenach about his presentation, "Causal Role of Oxidized Lipids in Pulmonary Hypertension Development," delivered for BCVS 2017 Early Career Pre-conference session.
Outstanding Early Career Award Finalists
Suppressing Microtubule Detyrosination Reduces Stiffness and Improves Contractility in Human Cardiomyocytes
Benjamin L Prosser, UPenn School of Medicine, Philadelphia, PA
- RESULTS: Early research demonstrates benefit of microtubule suppression in heart failure mechanics.
- Abstract
Identification of a Major Role for Cytochrome B5 Reductase 3 in Cardiomyocyte Metabolism and Function
Adam C Straub | University of Pittsburgh, Pittsburgh, PA
- RESULTS: Cyb5R3 plays a critical role in regulation of cardiomyocyte metabolism.
- Abstract
Glucose-Mediated Remodeling of Cardiac DNA Methylation
Adam R Wende | University of Alabama at Birmingham, Birmingham, AL
- RESULTS: Regulation of cellular function via DNA methylation in diabetic cardiomyopathy is directed by glycemic memory.
- Abstract
CD16 Monocytes Stimulate Arteriogenesis to Salvage the Ischemic Limb
Ashish S Patel | King's College London, London, United Kingdom
- RESULTS: Potential therapeutic role using tissue-remodeling monocytes expressing CD16 for critical limb ischemia patients.
- Abstract
The Success of Humanizing Miniature Hearts is the Right Cannulation
Duong T Nguyen | AstraZeneca, Molndal, Sweden
- RESULTS: Novel cannulation approach for preserving cardiac circulation may translate to humans.
- Abstract
Targeting Beta Adrenergic Receptor Resensitization Aids in Preservation of Receptor Function
Elizabeth E Martellli | Cleveland Clinic, Cleveland, OH
Presented by Sathyamangla V. Naga Prasad | Cleveland Clinic, Cleveland, OH
- RESULTS: Evidence that resensitization of beta adrenergic receptors is inhibited in heart failure suggests future therapeutic targets.
- Abstract
TAB2 is Molecular Switch That Critically Regulates Myocardial Survival and Necroptosis
Qinghang Liu | University of Washington, Seattle, WA
Presented by Xiaoyun Guo | University of Washington, Seattle, WA
- RESULTS: TAB2 found to be key regulator in myocardial cell death (necroptosis) and remodeling.
- Abstract
Cardiac Activation of β-catenin in Mice Leads to Prolongation of QRS and Susceptibility to Arrhythmia by Inhibiting Na+ Channel Activity Through Suppression of NaV1.5 Expression
Rong Huo | UCLA, Los Angeles, CA
- RESULTS: Mechanism for β-catenin’s role in arrhythmias described in pre-clinical study.
- Abstract
Two Different Microdomains of β1-adrenoreceptor Signaling Revealed by Live Cell Imaging
Alexander Froese | University Medical Center Hamburg, Hamburg, Germany
- RESULTS: Location, location – different microdomains result in different signaling for cardiomyocyte β1-adrenergic receptors.
- Abstract
There were plenty of awards given at BCVS17 this year. Visit the photo gallery to download and share yours.
Presenters, experts and more shared some great ideas. Visit the photo gallery to see all the action.