Science News from ATVB|PVD 2017
Arteriosclerosis, Thrombosis and Vascular Biology | Peripheral Vascular Disease
May 4 – 6, 2017
Hyatt Regency Minneapolis | Minneapolis, Minn.
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More Links: All 2017 Abstracts (PDF - large file) | ATVB|PVD 2017 ePosters and eAbstracts (opens in new window)(link opens in new window)
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Selected Science from Thursday, May 4
Welcome to ATVB|PVD 2017
Steven R. Houser, PhD, president of the American Heart | American Stroke Association, welcomes attendees to ATVB 2017 in Minneapolis.
Genome Editing 2017: Scientific, Clinical, and Ethical Implications
Kiran Musunuru, MD, PhD, MPH, William Lagor, PhD, and Joe Miano, PhD discuss the scientific and ethical implications of recent developments in genome editing using CRISPR-CAS9 technology and its potential role in advancing the mission of the American Heart Association.
Deletion of Macrophage Low-density Lipoprotein Receptor-related Protein 1 (LRP1) Accelerates Atherosclerosis Regression by Increasing CCR7-dependent Egress of Plaque Macrophages
Paul Mueller | Oregon Health and Science University, Portland, OR
- RESULTS: Mechanism described for acceleration of atherosclerosis regression when macrophages are deficient in Low-density Lipoprotein Receptor-related Protein 1 (LRP1).
- Abstract
Inhibition of Nudt6 Stabilizes Advanced Atherosclerotic Plaques
Hong Jin | Karolinska Institute, Stockholm, Sweden
- RESULTS: Atherosclerotic plaque rupture rates reduced with Nudt6 inhibition.
- Abstract
A Novel in vivo Endothelial Hierarchy from Progenitor to Mature Endothelial Cells Reveals Key SoxF-Dependent Differentiation Process
Jatin Patel | The University of Queensland, Brisbane, Australia
- RESULTS: Novel endovascular progenitor process for forming new vessels in multiple tissues described.
- Abstract
Systemic Administration of Target-Seeking, Vessel Penetrating Recombinant Decorin Fusion Protein, Car-DCN, Reduces Severity of Abdominal Aortic Aneurysm in Mice
Yue (Steve) Shen | University of British Columbia, Vancouver, BC, Canada
- RESULTS: Abdominal aorta wall reinforced with SAR-DCN use in early pre-clinical study of abdominal aortic aneurysm.
- Abstract
Genetic Neutrophil Deficiency Ameliorates Cerebral Ischemia-Reperfusion Injury
Ryan A Frieler | University of Michigan, Ann Arbor, MI
- RESULTS: Neutrophils play a role in the development of the infarction during stroke.
- Abstract
The Effects of Resveratrol Treatment on Vascular Function in Type 2 Diabetes Mellitus
Ji-Yao Zhang | Boston University School of Medicine, Whitaker Cardiovascular Institute, Boston, MA
Crosstalk Between Phosphotidylinositol-4,5 Bisphosphonate-3 Kinase Pathway and Mitogen-Activated Protein Kinase Pathway Regulates Platelet Activation and Protein Synthesis via Phosphoinositide-Dependent Kinase-1
Bhanu Kanth Manne, University of Utah, Salt Lake City, UT
- RESULTS: Crosstalk and signaling pathways responsible for platelet activation and thrombus formation studied.
- Abstract
Daniel Steinberg Early Career Investigator Award in Atherosclerosis/Lipoproteins
Deficiency of ATP-Binding Cassette Transporters A1 and G1 in Endothelial Cells Accelerates Atherosclerosis in Mice
Marit Westerterp | Groningen, Netherlands
Young Investigator Award Finalists
WINNER
Centrosome Destabilization Through the Ubiquitin-Proteasome Pathway Regulates Proplatelet Production
Kellie R Machlus | Harvard Medical School, Boston, MA
- RESULTS: Centrosome destabilization may trigger proplatelet formation; the Ubiquitin-Proteasome Pathway appears to be crucial.
- Abstract
Neutrophil-Derived S100a8 and S100a9 Promotes Reticulated Thrombocytosis and Atherogenesis in Diabetes
Prabhakara R Nagareddy | University of Alabama at Birmingham, Birmingham, AL
- RESULTS: Mechanisms of platelet production in hyperglycemia involve regulation by neutrophil-derived S100A8/A9.
- Abstract
Myeloid Klf2 Regulates Arterial and Venous Thrombosis
Lalitha Nayak | Case Western Reserve University, Cleveland, OH
- RESULTS: Mechanisms for neutrophil KLF2 regulation of thrombosis described.
- Abstract
Transcriptional Networks Specifying Homeostatic and Pro-Inflammatory Programs of Gene Expression in Human Aortic Endothelial Cells
Casey E Romanoski | University of Arizona, Tucson, AZ
Control of Macrophage Cholesterol Efflux and Atherogenesis by the Noncoding RNA MeXis
Tamer Sallam | David Geffen School of Medicine at UCLA, Los Angeles, CA
- RESULTS: MeXis identified as 'transcriptional gatekeeper' in regulating macrophage responses to elevated cholesterol.
- Abstract
Cholesterol Efflux Pathways Suppress Inflammasome Activation in Mice and Humans
Marit Westerterp | University of Groningen, Groningen, Netherlands
Failure of Protective Autoimmunity in Mouse and Human Atherosclerosis
Dennis Wolf | La Jolla Institute for Allergy and Immunology, La Jolla, CA
- RESULTS: Transformation of atherosclerosis-protective immune cells into pathogenic cells may suggest therapeutic targets.
- Abstract
FXR1 Regulates Inflammatory MRNA Stability and VSMC Proliferation by Modulation of HuR Activity
Allison Herman | Lewis Katz School of Medicine, Philadelphia, PA
- RESULTS: IL-19 decreases vascular inflammation by inducing FXR1, and by reducing HuR activity.
- Abstract
Disruption of PCSK9 Using a Targeted Base Editing Strategy
Alexandra C. Chadwick | University of Pennsylvania, Philadelphia, PA
- RESULTS: Base-editing results for PCSK9 disruption. New genome-editing science may prove to be a strategy for lipid management.
- Abstract
High Density Lipoprotein Mediated Protection of Macrophages Against Apoptosis Requires Scavenger Receptor Class B Type 1 Activity and Sphingosine-1-Phosphate
Kevin Chathely | McMaster University, Hamilton, ON, Canada
- RESULTS: Possible mechanisms of HDL protection against macrophage apoptosis may reveal treatment targets to slow atherosclerosis progression.
- Abstract
Effects of Muscle Stretching on Flow-Mediated Dilation of Popliteal Artery in Patients With Peripheral Artery Disease
Kazuki Hotta | Florida State University College of Medicine, Tallahassee, FL
- RESULTS: Calf muscle stretching aids walking tolerance for PAD patients.
- Abstract
- AHA News Article: Stretching may reduce leg pain in peripheral artery disease patients
- AHA Newsroom Press Release
Klaus Ley, Distinguished Lecturer ATVB|PVD 2017
Klaus Ley, MD, ATVB/PVD 2017 Distinguished Lecturer, talks about his research into the potential for exploiting protective autoimmunity to develop a vaccine against atherosclerosis and the importance of the American Heart Association to scientific research efforts.
Global and Liver Specific Bmal1 Deficient Mice Regulate Intestinal Lipid Absorption
Xiaoyue Pan | Winthrop University Hospital, Mineola, NY
- RESULTS: Global and liver-specific Bmal1 appears to regulate intestinal lipid absorption.
- Abstract
Cinnamon Extract Inhibit Lipids and Inflammation by Modulation of Transcription Factors: in vivo Model
Vijaya Juturu | OmniActive Health Technologies Inc, Morristown, NJ
- RESULTS: Animal study suggests polyphenols in cinnamon extract may reduce CVD risk factors including inflammation, hyperlipidemia, and oxidative stress.
- Abstract