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ATVB Journal Header Centered 750x266

ATVB Featured Articles
March 2020

ATVB_cover_March 2020_600 px
 
About the Cover

The activation of Rac1 in the calcifying aortic plaque of atherosclerosis-prone mice treated with atorvastatin. In macrophages,
atorvastatin inhibits the interaction between Rac1 and its primary inhibitor, RhoGDI, leading to activated (GTP-bound) Rac1.
(See pages 714–732.)
 

Editor's Pick

ATVB_March 2020  Fig 01.jpg

VLDL (Very-Low-Density Lipoprotein)-Apo E (Apolipoprotein E) May Influence Lp(a) (Lipoprotein [a]) Synthesis or Assembly
Mikaël Croyal, Valentin Blanchard, Khadija Ouguerram, Maud Chétiveaux, Léa Cabioch, Thomas Moyon, Stéphanie Billon-Crossouard, Audrey Aguesse, Karine Bernardeau, Cédric Le May, Laurent Flet, Gilles Lambert, Samy Hadjadj, Bertrand Cariou, Michel Krempf, Estelle Nobécourt-Dupuy  

Editor's Note:
This article reports Lp(a) kinetics in patients with loss-of-function and gain-of-function PCSK9 mutations, and in patients in whom extended-release niacin reduced Lp(a) and PCSK9 concentrations. VLDL-apoE production can determine Lp(a) production or assembly. ApoE links PCSK9 and Lp(a).

https://www.ahajournals.org/doi/10.1161/ATVBAHA.119.313877

 

Featured Articles

ATVB_March 2020  Fig 02.jpg

Retinoids repress human cardiovascular cell calcification with evidence for distinct selective retinoid modulator effects

New evidence for distinct, selective, species-specific #retinoid modulation of human #cardiovascular calcification, #APOC3 secretion, and #bone mineralization.

https://www.ahajournals.org/doi/10.1161/ATVBAHA.119.313366
 

 

ATVB_March 2020  Fig 03.jpg

PIM1 inhibition decreases the NHEJ DNA damage repair signaling pathway in pulmonary hypertension

Pim1 regulates DNA damage repair in Pulmonary Arterial Hypertension (PAH) and pharmacologic inhibitors improve pulmonary pressure and vascular remodelling in PAH animal models.

https://www.ahajournals.org/doi/10.1161/ATVBAHA.119.313763

 

 


 

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