Science News from IKDS 2015

International Kawasaki Disease Symposium 2015
February 3–6, 2015 | Honolulu, HI

Kawasaki disease (mucocutaneous lymph node syndrome) is a children's illness characterized by fever, rash, swelling of the hands and feet, irritation and redness of the whites of the eyes, swollen lymph glands in the neck, and irritation and inflammation of the mouth, lips and throat.

The heart may be affected in as many as one of five children who develop Kawasaki disease. Damage sometimes occurs to the blood vessels that supply the heart muscle (the coronary arteries) and to the heart muscle itself.

Welcome to IKDS 2015
Program chairs Dr. Bryan McCrindle and Dr. Anne Rowley, along with AHA president Dr. Elliott Antman, welcome you to IKDS 2015 and provide an overview of the latest science and challenges for Kawasaki Disease.

Parent Troy Sato and his 2 ½-year-old twins Maya and Will. Maya was diagnosed with KD when she was 3 months old.

KD Across The Years - Part 1
AHA President Dr. Elliott Antman and Dr. Jane Newburger interview Dr. Tomisaku Kawasaki about the symptoms that led to his identification of the new disease that now bears his name in Part One of this exclusive interview.

KD Across The Years - Part 2
In the second part of our interview with Dr. Kawasaki, the pathophysiology of KD, the heart, and stroke are discussed.

Tuesday's Selected Science

Tuesday's Takeaways
IKDS program chairs Anne Rowley, MD, and Brian McCrindle, MD, discuss the science presented during Tuesday’s IKDS sessions and put the findings into perspective for clinicians and researchers.

Whole Genome Sequencing of a six-member African American family with two Kawasaki disease-affected siblings identifies novel susceptibility variants
Jihoon Kim | Division of Biomedical Informatics, Department of Medicine, University of California San Diego, La Jolla, CA

Histopathological Analysis of Sudden Death Adults with Coronary Artery Aneurysms
Kei Takahashi | Toho University Ohashi Medical Center, Tokyo, Japan

Microbiome Analysis in Kawasaki Disease
Kristine Wylie | The Genome Institute, Washington University School of Medicine, St. Louis, MO

Wylie's Presentation Slides (PDF)

Analysis of the Mechanisms of Intravenous Immunoglobulinresistant Kawasaki Disease Using iPS Cell Technology
Kazuyuki Ikeda | Kyoto Prefectural University of Medicine, Kyoto, Japan

Wednesday's Selected Science

Wednesday's Takeaways
IKDS program chairs Anne Rowley, MD, and Brian McCrindle, MD discuss the science presented during Wedesday’s International Kawasaki Disease Symposium, including pathology, diagnosis and biomarkers, the immunology and immunogenetics of KD, and medical treatment of KD.

Genetics of Kawasaki Disease
Jane Burns, MD, and Professor Yoshihiro Onouchi discuss the latest science connecting genetics and Kawasaki disease in the context of translational medicine.

Immunology of Kawasaki Disease
Michael Portman, MD, and Sadeep Shrestha, PhD, MS, along with Brian McCrindle, MD and Anne Rowley, MD, discuss possible environmental factors in the immunology, immunopathology, and immunogenetics of Kawasaki Disease.

Gut Microflora Influences Pathology in the Kawasaki Disease Vasculitis Mouse Model
Daiko Wakita | Cedars-Sinai Medical Center, Los Angeles, CA

Novel Biomarker for Early Diagnosis of Kawasaki Diseases
Tai-Ming Ko | Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan

Tenascin-C can be a Novel Prognostic Biomarker for Kawasaki Disease
Kyoko Imanaka-Yoshida | Mie University Graduate School of Medicine, Tsu, Japan

Assessment of Kawasaki Disease Risk Scores for Predicting Coronary Artery Aneurysms at a North American Center
Mary Beth F. Son | Boston Childrens Hospital, Boston, MA

Favorable Outcome of Patients with Kawasaki Disease Treated with Unified Protocol with Cyclosporine A as the Third Line Therapy
Hiromichi Hamada | Tokyo Women’s Medical University, Yachiyo Medical Center, Yachiyo, Japan

Thursday's Selected Science

Thursday's Takeaways
Program Chairs Anne Rowley, MD, and Brian McCrindle, MD, discuss Thursday's science presented at IKDS 15, including new imaging modalities, medical management and revascularization, the role of families and parents, lifestyle and psychosocial issues, the importance of collaborations across institutions, and tools for evaluating prognosis and outcomes.

IKDS 2015: Conference Highlights and Next Steps
Anne Rowley, MD, and Brian McCrindle, MD along with Jane Newburger, MD and Jane Burns, MD discuss the science presented during the 2015 International Kawasaki Disease Symposium. Highlights of the meeting’s science as well as challenges and needs for the future are shared.

Occult Coronary Artery Dilatation: An Unrecognized Category of Coronary Involvement
Soha Rached-d’Astous | Centre hospitalier universitaire Sainte-Justine, Division of Pediatric Cardiology, Montreal, QC, Canada

Kawasaki Disease Complicated by Coronary Artery Aneurysms: Mortality and 40-year Outcomes
Cedric Manlhiot | The Hospital for Sick Children, Toronto, ON, Canada

Characteristics and Fate of Systemic Artery Aneurysm caused by Kawasaki disease
Shinsuke Hoshino | Shiga University of Medical Science, Shiga, Japan

Exercise Response in Children and Adolescents Late After Kawasaki Disease According to Early Coronary Status
Nagib Dahdah | Centre hospitalier universitaire Sainte-Justine, Division of Pediatric Cardiology, Montreal, QC, Canada

The Spectrum of Cardiovascular Lesions Requiring Intervention in Young Adults after Kawasaki Disease
John B. Gordon | San Diego Cardiac Center, San Diego, CA

Transition to Adult Care
Adrienne Kovacs | University Health Network, Toronto, ON