Science News from BCVS 2018

Basic Cardiovascular Sciences 2018 Scientific Sessions

July 30–August 2, 2018
Grand Hyatt San Antonio | San Antonio, Texas

This is where you will find exclusive interviews with experts and newsmakers from BCVS 2018. Results below will be released at time of presentation. Please observe AHA's embargo policy.

Featured Science from Monday, July 30


Welcome to BCVS 2018

Joseph C. Wu, MD, PhD, chair of the Council on Basic Cardiovascular Sciences, interviews AHA President Ivor Benjamin about the importance of the council to his career and to the AHA mission.


BCVS 2018 Program Highlights

Program Co-Chairs Michael S. Kapiloff, MD, PhD, Rong Tian, MD, PhD, and Jennifer Van Eyk, PhD describe some of the highlights they have planned for the program for BCVS 2018 in San Antonio.


Epigenetic Regulation of Cardiac Fibrosis

Rong Tian, MD, PhD, Program Co-Chair, interviews Dr. Timothy A. McKinsey, PhD about his breakthrough research on cardiac fibrosis that he presented during BCVS 2018.

Chen Gao | UCLA-Los Angeles, Los Angeles, CA

Cytosolic RBFox1 in Cardiac Pathological Remodeling
Chen Gao | UCLA-Los Angeles, Los Angeles, CA

  • RESULTS: Cardiac expression of RBFox1c, an isoform of the nuclear RBFox1, results in suppression of proinflammatory genes and reduced cardiac fibrosis in response to myocardial infarct injury.
  • Abstract for Gao (opens in new window)
CNolan Thorne Carew | University of Pittsburgh, Pittsburgh, PA

Cytochrome b5 Reductase 3 Regulates Myoglobin Redox State and Controls Cardiac Function
Nolan Thorne Carew | University of Pittsburgh, Pittsburgh, PA

Haodi Wu | Stanford University, Stanford, CA

Modeling of Diastolic Dysfunction in Induced Pluripotent Stem Cell-derived Cardiomyocytes From Hypertrophic Cardiomyopathy Patients
Haodi Wu | Stanford University, Stanford, CA

  • RESULTS: Novel mechanisms for diastolic dysfunction, as well as possible treatment targets, were identified at the single-cell level using patient-specific induced pluripotent stem cell-derived cardiomyocytes from hypertrophic cardiomyopathy patients.
  • Abstract for Wu (opens in new window)
Leonardo J Leon |University of California San Diego, San Diego, CA

MCL-1Matrix Promotes Mitochondrial Fusion and Protects Against TAC Induced Hypertrophy
Leonardo J Leon |University of California San Diego, San Diego, CA

  • RESULTS: Overexpression of the cardiac MCL-1Matrix protein promotes mitochondrial enlargement in heart muscle cells, reducing stress during cardiac pressure overload.
  • Abstract for Leon (opens in new window)
Tara Tassin | UT Southwestern Medical Center, Dallas, TX

Mechanistic Insights into Duchenne Muscular Dystrophy-Associated Cardiomyopathy
Tara Tassin | UT Southwestern Medical Center, Dallas, TX

Featured Science from Tuesday, July 31


BCVS 2018 Keynote Lecture

Joseph C. Wu, MD, PhD, Chair, Council on Basic Cardiovascular Sciences, interviews Keynote Lecturer Stefanie Dimmeler, PhD about her latest work on Cellular Heterogeneity and Plasticity in Cardiovascular Disease.


Feeding the Starving Failing Heart

Gary Lopaschuk, PhD interviews Daniel P. Kelly, MD about his research exploring the use of ketones as a possible therapy for heart failure.

TMarta Adamiak | Icahn School of Medicine at Mount Sinai, New York, NY

AAV-Exosomes: A Novel Platform for Myocardial Gene Delivery for Cardioprotection
Marta Adamiak | Icahn School of Medicine at Mount Sinai, New York, NY

Effective Three-element Windkessel Model based on Doppler Ultrasound Images for Noninvasive Quantification of Trans-stenotic Pressure Gradient in Aortorenal System
Monsurul Khan | Indiana University-Purdue University Indianapolis, Indianapolis, IN

  • RESULTS: Image-based computational hemodynamics (ICH) tool may aid stenting decision-making by non-invasively measuring aortorenal pressure gradients in renal artery stenosis (RAS).
  • Abstract for Khan (opens in new window)
Alexa Wnorowski | Stanford University, Stanford, CA

Effects of Microgravity on Human Induced Pluripotent Stem Cell-Derived Cardiomyocyte Structure and Function
Alexa Wnorowski | Stanford University, Stanford, CA

  • RESULTS: Microgravity experienced on the International Space Station impacts heart function at a cellular level, and includes changes in gene expression, structure and function.
  • Abstract for Wnorowski (opens in new window)
Shuin Park | University of California, Los Angeles, Los Angeles, CA

Exclusion of Major Cell Types in the Murine Heart Enriches for Cardiac Pericytes
Shuin Park | University of California, Los Angeles, Los Angeles, CA

  • RESULTS: Exclusion of other cell-types and RNA-sequencing has identified subpopulations of cardiac pericytes; further study needed to determine their different functions.
  • Abstract for Park (opens in new window)
Junco S Warren | University of Utah, Salt Lake City, UT

Perm1 is a Novel Regulator of Mitochondrial Energetics in Cardiomyocytes
Junco S Warren | University of Utah, Salt Lake Cty, UT

  • RESULTS: PERM 1 has a novel role in mitochondrial energetics regulation. Downregulation of PERM 1 in cardiomyocytes may reduce mitochondrial function during heart failure.
  • Abstract for Warren (opens in new window)
Anja Karlstaedt | McGovern Medical School at UTHealth, Houston, TX

Alpha-Ketoglutarate Dehydrogenase Inhibition by the Oncometabolite D2-HG Causes Proteome and Metabolome Remodeling in Myocytes
Anja Karlstaedt | McGovern Medical School at UTHealth, Houston, TX

  • RESULTS: The oncometabolite D-2-hydroxyglutarate (D2-HG) inhibits alpha-ketoglutarate dehydrogenase inhibition in myocytes, resulting in an increase in proteomic remodeling and metabolomic changes.
  • Abstract for Karlstaedt (opens in new window)

Featured Science from Wednesday, August 1

Using Personalized Cell Models to Identify a Common Protein Present in AF Patients with HFpEF

Jennifer Strande, MD describes her recent research using personalized cell models and machine learning to identify a common protein that seems to be a factor contributing to heart failure with preserved ejection fraction in patients with atrial fibrillation.

Yun Chen | Albert Einstein College of Medicine, Bronx, NY

Regulation of Cardiac Mitochondrial Function by Chaperone Mediated Autophagy
Yun Chen | Albert Einstein College of Medicine, Bronx, NY

David Y Barefield | Northwestern University, Chicago, IL

Mybphl is a Novel Myofilament Component Implicated in Arrhythmia and Dilated Cardiomyopathy
David Y Barefield | Northwestern University, Chicago, IL

  • RESULTS: Loss of the novel myofilament component, MyBP-HL, impaired the ventricular conduction system and was associated with ventricular arrhythmia and dilated cardiomyopathy.
  • Abstract for Barefield (opens in new window)
Daniel N Meijles | St George's University of London, London, United Kingdom

Cardiomyocyte Braf Promotes Hypertrophy and is Required for Hypertrophic Adaptation to Hypertension in Mice In Vivo, but Raf Inhibitors Have Differential Effects
Daniel N Meijles | St George's University of London, London, United Kingdom

  • RESULTS: Raf inhibitors (Rafi), used to inhibit Braf mutations in cancer, demonstrated differing effects on the heart compared to the protective effects of non-mutated Braf.
  • Abstract for Meijles (opens in new window)
Huabo Su | Augusta University, Augusta, GA

The Ufm1 Specific Ligase 1 Regulates Endoplasmic Reticulum Homeostasis and Protects Against Heart Failure
Huabo Su | Augusta University, Augusta, GA

  • RESULTS: The Ufm1 system may be key to cardiac homeostasis by regulation of endoplasmic reticulum function; Ufl1 may have a role in heart failure protection.
  • Abstract for Su (opens in new window)

Wednesday News Releases:

Serum Leptin and TNFa Levels in Relation to Systolic and Diastolic Heart Function in Obese and Normal-overweight Pregnant. First Trimester Data
Katherine Shreyder | Texas Tech University Health Sciences Center, Odessa, TX

Thursday, August 2


Outstanding Early Career Award Winner Manuel Rosa-Garrido, PhD

Immediate Past BCVS Council Chair Ronglih Liao, PhD interviews Manuel Rosa-Garrido, PhD about his research using Hi-C data to explore the role of chromatin in heart failure. Read his abstract here (opens in new window).


BCVS 2018 Wrap-Up from the Program Co-Chairs

Program Co-Chairs Michael S. Kapiloff, MD, PhD, Rong Tian, MD, PhD, and Jennifer Van Eyk, PhD review a successful week at BCVS 2018 in San Antonio.

Outstanding Early Career Investigator Award Finalists

Manuel Rosa-Garrido | UCLA, Los Angeles, CA

WINNER
Chromatin Microenvironments With Distinct Functionality During Cardiac Stress
Manuel Rosa-Garrido | UCLA, Los Angeles, CA

Lisandra E de Castro Brás | East Carolina Univ, Greenville, NC

Steering Fibroblast Phenotype to Promote Left Ventricular Scar Maturation and Function Post-MI
Lisandra E de Castro Brás | East Carolina University, Greenville, NC

Cristi L Galindo | Vanderbilt University Medical Center, Nashville, TN

A Role for Brain-derived Neurotrophic Factor in Duchenne Cardiomyopathy
Cristi L Galindo | Vanderbilt University Medical Center, Nashville, TN