Science News from BCVS 2019

Basic Cardiovascular Sciences 2019 Scientific Sessions

July 29–August 1, 2019
Westin Boston Waterfront | Boston, Massachusetts

Monday's selected science


BCVS 2019 Welcome and Program Highlights

BCVS program co-chairs Sakthivel Sadayappan, Jil Tardiff, and Loren Wold welcome attendees to BCVS 2019 in Boston and share some of the program highlights they have planned for the meeting this year.


Exploring the Role of the Extracellular Matrix in Heart Failure

BCVS 2019 Co-Chair Jil Tardiff interviews Steven Jones about his recent work exploring the role of the extracellular matrix in heart failure.

Francisco Altamirano | UT Southwestern Medical Center, Dallas, TX

Polycystin-1 Assembles With Kv Channels to Govern Cardiomyocyte Repolarization and Contractility
Francisco Altamirano | UT Southwestern Medical Center, Dallas, TX

  • RESULTS: A novel role is uncovered for PC1 controlling action potential duration and SERCA. PC1-deficient cardiomyocytes manifest impaired contractility, likely contributing to contractile dysfunction in autosomal dominant polycystic kidney disease (ADPKD) patients.
  • Altamirano's Abstract (opens in new window)
Masahiro Kimura | Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan

Homeobox A4 Suppresses Vascular Smooth Muscle Cell Phenotypic Switching as a Novel Regulator of YAP/TEAD Transcriptional Activity
Masahiro Kimura | Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan

Neonatal Mouse Heart Regeneration is Dependent on Mononuclear Diploid Cardiomyocytes and Paracrine IGF2 Signaling
Henry M Sucov | Medical University of South Carolina, Charleston, SC

NFkB Promotes Oxidative Stress-induced Necrosis and Ischemia Reperfusion Injury Through NRF2-ARE Pathway
Qinghang Liu | University of Washington, Seattle, WA

Frank J Raucci Jr | Vanderbilt University Medical Center, Nashville, TN

Cardioprotective Effects of Brain-derived Neurotrophic Factor rs6265 Polymorphism in Duchenne Cardiomyopathy
Frank J Raucci, Jr. | Vanderbilt University Medical Center, Nashville, TN

Tuesday's selected science

Keynote Lecturer Christine Seidman on Genetic Approaches to Cardiomyopathy

BCVS Council Vice Chair Beth McNally and BCVS 2019 Co-Chair Jil Tardiff interview Keynote Lecturer Christine Seidman about her recent work on the genetics of dilated and hypertrophic cardiomyopathy and how it might be harnessed to develop new, earlier treatments.

Using Cardiac Organoids to Develop New Drug Therapies for Heart Failure

BCVS Council Chair Joseph Wu interviews James Hudson of QIMR Berghofer Medical Research Institute in Queensland, Australia, about his work using cardiac organoids to identify new targets for developing new drug therapies for treating heart failure.

Alexandra G Moyzis | University of California San Diego, San Diego, CA

MCL-1 Promotes Drp1-Mediated Mitochondrial Fission as an Adaptive Response to Stress
Alexandra G Moyzis | University of California San Diego, San Diego, CA

Frone Vandewiele | KU Leuven, Leuven, Belgium

Trpm4 Contributes to Ca2+-dependent Triggered Arrhythmias in Pathological Conditions
Frone Vandewiele | KU Leuven, Leuven, Belgium

Danielle S Murashige |  University of Pennsylvania, Philadelphia, PA

Comprehensive Arteriovenous Metabolomics in the Human Heart
Danielle S Murashige | University of Pennsylvania, Philadelphia, PA

Wednesday's selected science

Genetic Approaches to Identify and Treat Cancer Patients at High Risk for Cardiotoxicity

BCVS 2019 Co-Chair Sakthivel Sadayappan interviews Paul Burridge about his recent work using genetic approaches to identify and treat the cancer patients most at risk of doxorubicin cardiotoxicity and subsequent heart failure.

Learning how to Leverage Brown Adipose Tissue to Regulate Cardiac Function

BCVS 2019 Co-Chair Loren Wold interviews Kristin Stanford about her research into the role brown adipose tissue plays in the regulation of cardiac function.

Njabulo Ngwenyama | Tufts University, Boston, MA

Endogenous-Antigen-Specific T Cell Receptor Activation of CD4+ T Cells in the Heart is Required for Maladaptive Cardiac Remodeling Due to Pressure Overload
Njabulo Ngwenyama | Tufts University, Boston, MA

  • RESULTS: Endogenous-antigen-specific T cell receptor activation of CD4+ T cells in the heart is required for maladaptive cardiac remodeling due to pressure overload-induced HF.
  • Ngwenyama's Abstract (opens in new window)
Qinghang Liu | University of Washington, Seattle, WA

A Novel Ubiquitination Dependent Pathway Regulating Myocardial Necroptosis and Ischemic Injury
Qinghang Liu | University of Washington, Seattle, WA

Allen C.T. Teng | University of Toronto, Toronto, ON, Canada

Reduced Cardiac Transmembrane Protein 65 Resulted in Dilated Cardiomyopathy and Progressive Cardiac Fibrosis in vivo
Allen C.T. Teng | University of Toronto, Toronto, ON, Canada

Liang Hong | University of Illinois Chicago, Chicago, IL

Downregulation of the Cardiac Sodium Channel Nav1.5 Mediates Obesity-Induced Atrial Fibrillation
Liang Hong | University of Illinois Chicago, Chicago, IL

Thursday's selected science

BCVS 2019 - What We Learned

Co-Chairs Loren Wold, Jil Tardiff, and Sakthivel Sadayappan recap some of the highlights and innovations of BCVS 2019, and invite you to next year's conference.

Outstanding Early Career Award Winner Luigi Adamo

Farah Sheikh interviews Luigi Adamo, this year's winner of the BCVS Outstanding Early Career Investigator Award for his groundbreaking research on the role of myocardial B cells in regulating the composition of leukocytes in the heart and myocardial growth (opens in new window).

Precision Intervention of Cardiac Remodeling Based on Cellular Composition Principles Uncovered by Single-Cell Transcriptomics
Peng Yu | Fuwai Hospital, Beijing, China

Reliability Analysis for Image-based Non-invasive Pressure Quantification in Aortorenal Artery System
Xiaoping Du | Indiana University-Purdue University, Indianapolis, Indianapolis, IN

  • RESULTS: Reliability analysis for image-based non-invasive pressure quantification in aortorenal artery systems finds greater systolic pressure uncertainty in the aorta than the renal arteries.
  • Du's Abstract (opens in new window)

Asian Cardiovascular Symposium

Speakers and program organizers of South Asian Heart Association

Members of the South Asian Heart Association (SAHA) joined three other groups for the first Asian Cardiovascular Symposium, held Sunday, July 28 2019 in Boston. The symposium was well-attended and included members of the Academy of Cardiovascular Research Excellence (ACRE), the Japanese Cardiovascular Group (JCS), and the Korean Cardiovascular Society (KCS).

A summit attendee listens to a poster author explain his science.

The symposium featured oral and poster presentations, as well as a dinner and award ceremony. The ACS gives cardiovascular professionals from across the world a chance to network and learn the latest in cardiovascular prevention and science.

Wally Koch, PhD, speaks to attendees at the first Asian Cardiovascular Summit at BCVS 2019.

This year's keynote speaker was Walter J. Koch, PhD, of the Lewis Katz School of Medicine at Temple University in Philadelphia. See and download more photos from the Asian Cardiovascular Symposium. (link opens in new window)