Science News

International Stroke Conference 2019

Nursing Symposium & Pre-Con Symposia: Feb. 5, 2019
Sessions: Feb.6–8, 2019
Honolulu, Hawaii


ISC 2019 Program Highlights

Program Committee Chair Miguel Perez-Pinzon, PhD and Vice-Chair Louise McCullough, MD, PhD welcomed attendees to ISC 2019 and review some of the highlights planned this year.


Pre-Con II: Stroke in the Lab World

Dr. Pinzon interviews Sunghee Cho, PhD, and Joseph LaManna, PhD, co-chairs for the Pre-Con II Session about its theme: Cutting Edge Topics in Experimental Stroke Research.

Tuesday's Selected Science

Stephanie Meletis 300x300 photo

Hands-On Curriculum Educates Neuroscience Nurses on Bedside Swallow Screening
Stephanie Meletis | University of Chicago, Chicago, IL


Jennifer Sanner 300x300 photo

Identifying and Understanding Factors Associated with Post-Stroke Anxiety
Jennifer Sanner | UT Health Cizik School of Nursing, Houston, TX


Aileen Chan 300x300 photo

Effectiveness of a Caregiver-Centered Empowerment Program for Chinese Stroke Family Caregivers
Aileen W Chan | The Nethersole School of Nursing, The Chinese University of Hong Kong, Hong Kong


Amanda James 300x300 photo

Nurse Advocacy in the Development of Outpatient Stroke Clinics: Led and Managed by Nurses
Amanda James | Medical University of South Carolina, Charleston, SC

Wednesday's Selected Science


SHINE Trial Results

Louise McCullough, MD, vice chair for ISC 2019, interviews Karen Johnston, MD, principal investigator of the SHINE trial about the results and their significance for patients and clinicians. (Jump to the SHINE science)


RIGHT-2 Interview with PI Philip Bath, MD, DSc

Louise McCullough, MD, PhD interviews Philip Bath, MD, DSc, principal investigator of the RIGHT-2 trial, about the prehospital administration of TNG in ultra-acute stroke. (Jump to the RIGHT-2 Science)


ISC 2019 Wednesday Highlights

Louise McCullough, MD, PhD and Miguel Perez-Pinzon, PhD provide a recap of select Day 1 clinical trials.

Karen Johnston 300x300 photo

Stroke Hyperglycemia Insulin Network Effort (SHINE) Trial Primary Results
Karen C Johnston | University of Virginia, Charlottesville, VA

Philip Bath 300x300 photo

Glyceryl Trinitrate for Pre-hospital Ultra-acute Stroke: Main Results From the Rapid Intervention With Glyceryl Trinitrate in Hypertensive Stroke Trial-2 (RIGHT-2)
Philip M Bath | University of Nottingham, Nottingham, United Kingdom

Setareh Salehi Omran 300x300 photo

Increasing Rate of Stroke From Infective Endocarditis Related to Opioid Abuse in the U.S.
Setareh Salehi Omran | Feil Family Brain and Mind Research Institute and Department of Neurology, Weill Cornell Medical College, New York, NY

Sunil Sheth 300x300 photo

Outcomes After Endovascular Stroke Therapy in High Versus Low Volume Centers
Sunil A Sheth | UT Health, McGovern School of Medicine, Houston, TX

Sandro Marini 300x300 photo

Apolipoprotein E and Intracerebral Hemorrhage: A Trans-Ethnic Meta-Analysis
Sandro Marini | Massachusetts General Hospital, Boston, MA

Yejie Shi300x300 photo

Apoptosis Signal-Regulating Kinase 1 (ASK1) is a Novel Master Molecular Switch Controlling Microglia/Macrophage Reactions That Impact Short- and Long-Term Stroke Outcomes
Yejie Shi | University of Pittsburgh, Pittsburgh, PA

Edward C Koellhoffer 300x300 photo

Circulating Peripheral Factors Induce Age-Related Epigenetic Changes in Microglia Which Induces a Primed Phenotype
Edward C Koellhoffer | UT Health McGovern Medical School, Houston, TX

Juneyoung Lee 300x300 photo

Stroke Impairs Epithelial Microfold Cells in Intestinal Peyer's Patches
Juneyoung Lee | UT Health Houston, Houston TX

Ashkan Shoamanesh 300x300 photo

Cerebral Microbleeds and the Effect of Anticoagulation on Outcomes in 3699 Patients With Embolic Strokes of Undetermined Source: An Exploratory Analysis of the NAVIGATE ESUS Trial
Ashkan Shoamanesh | McMaster University, Hamilton, ON, Canada

Kazunori Toyoda 300x300 photo

Dual Antiplatelet Therapy Using Cilostazol for Secondary Stroke Prevention in High-risk Patients: The Cilostazol Stroke Prevention Study for Antiplatelet Combination (CSPS.com)
Kazunori Toyoda | National Cerebral and Cardiovascular Center, Suita Osaka, Japan

Xiaoming Hu 300x300 photo

Interleukin 4 Improves White Matter Repair After Stroke By Promoting Oligodendrocyte Differentiation
Xiaoming Hu | University of Pittsburgh, Pittsburgh, PA

Audience members at ISC19

Audience members listen to a presentation on Wednesday at ISC19. See and share more photos from the conference.

Ivor Benjamin on Screen at ISC19

If you missed AHA/ASA president Ivor Benjamin addressing the conference, read his speech here.

Luncheon at ISC19

Attendees shared ideas and made new friends at the Advance Practice Providers Luncheon on Wednesday.

Thursday's Selected Science


MISTIE 3 Results

Bruce Ovbiagele, MD, MSc, MAS, MBA interviews Dan Hanley, MD and Issam Awad, MD, co-principal investigators of the MISTIE 3 trial about what the clinical and surgical results suggest for treating patients with ICH. (Jump to the MISTIE science)


ISPOT Results

Louise McCullough, MD, PhD interviews Nina Gentile, MD, principal investigator of iSPOT, about the purpose and results of the trial and how it relates to the SHINE trial presented on Wednesday. (Jump to the iSPOT science)


ISC19 Thursday Science Highlights

Louise McCullough, MD, PhD and Miguel Perez-Pinzon, PhD review select science presented on Day 2 of ISC 2019 in Honolulu.

 

Endovascular Therapy Outcomes in Large Core

Peter Panagos, MD interviews Amrou Sarraj, MD about his recent work on endovascular thrombectomy outcomes in large core, which he presented in multiple sessions for ISC 2019. (Jump to the EVT Large Core science)

Daniel Hanley 300x300 photo

MISTIE 3 Trial Results
Daniel F Hanley | Johns Hopkins University, Baltimore, MD

Issam A Awad 300x300 photo

MISTIE III Surgical Results: Efficiency of Hemorrhage Removal Determines mRS
Issam A Awad | University of Chicago, Chicago, IL

Amrou Sarraj 300x300 photo

Endovascular Thrombectomy Outcomes in Large Core on CT Are Strongly Associated With Perfusion Core Volume and Time: Implications From Two Large Cohorts for Future Trials
Amrou Sarraj | UT Health Science Center At Houston, Houston, TX

Nina Gentile 300x300 photo

Insights on Selected Procoagulation Markers and Outcomes in Stroke Trial (iSPOT) Primary Results
Nina T. Gentile | Temple University, Philadelphia, PA

Yorito Hattori 300x300 photo

ApoE4 Disrupts Cerebrovascular Microcirculation and Undermines White Matter Integrity and Cognitive Function
Yorito Hattori | Weill Cornell Med, New York, NY

Jacob Hudobenko 300x300 photo

Amelioration of Ischemic Stroke Damage Through Inhibition of Interleukin-6 Signaling With Tocilizumab Requires Sex Specific Dosing
Jacob Hudobenko | UT Health Science Center at Houston, Houston, TX

Craig Anderson 300x300 photo

Main Results of the Enhanced Control of Hypertension and Thrombolysis Stroke Study (enchanted) of the Early Intensive Blood Pressure Control After thrombolysis
Craig Anderson | The George Institute for Global Health, UNSW, Sydney, Australia

Truman John Milling Jr. 300x300 photo

Andexanet Alfa for Treatment of Factor Xa Inhibitor-related Acute Major Bleeding
Truman John Milling Jr. | Seton Dell Medical School Stroke Institute, Austin, TX

Kazuo Kitagawa 300x300 photo

A Randomized Trial of Intensive versus Standard Blood-Pressure Control in Patients with a History of Stroke:The Recurrent Stroke Prevention Clinical Outcome (RESPECT) Study
Kazuo Kitagawa | Tokyo Women's Medical University, Tokyo, Japan

  • RESULTS: Stroke recurrence was not reduced by intensive BP lowering compared to standard BP treatment for secondary prevention in patients with a history of stroke.
  • Kitagawa's Abstract (new window)

Effects of a Quality Improvement Intervention on Adherence to Evidence-based Therapies for Acute Ischemic Stroke and Transient Ischemic Attack Patients in Hospitals With Stroke Units - Insights From the BRIDGE Stroke Trial
M. Julia Machline Carrion | Heart Hospital, Sao Paulo, Brazil

Spenopalatine-ganglion Stimulation for the Treatment of Acute Ischemic Stroke: Pooled Meta-analysis of the Impact 24A and Impact 24B Trials
Ashfaq Shuaib on behalf of ImpACT-24 Steering Committee | University of Alberta, Edmonton, AB, Canada

  • RESULTS: Pooled analysis of these 2 trials showed that stimulation of the sphenopalatine ganglion within 24 hours of anterior AIS resulted in improved functional outcomes.
  • Shuaib's Abstract (new window)

Treatment of Carotid Stenosis in Asymptomatic, Non-Octogenarian, Standard Risk Patients with Stenting versus Endarterectomy: A Pooled Analysis of the CREST and ACT I Trials
Jon S Matsumura | University of Wisconsin, Madison, WI

  • RESULTS: Comparing the results of the CREST and ACT l trials in patients with asymptomatic carotid stenosis found similar results short- and long-term for the composite of stroke, heart attack, or death during the periprocedural period or any ipsilateral stroke within 4 years for carotid artery stenting with embolic protection (CAS) compared to carotid endarterectomy (CEA).
  • Matsumura's Abstract (new window)
  • Matsumura's Presentation Slides (PDF)

Secondary Stroke Prevention by Uniting Community and Chronic Care Model Teams Early to End Disparities: The SUCCEED Trial
Amytis Towfighi | University of Southern California, Los Angeles, CA

Newton-2: Randomized, Double-blind, Placebo-controlled Study of Eg-1962 in Adults With Aneurysmal Subarachnoid Hemorrhage
Stephan A. Mayer, Mount Sinai Hospital, New York, NY

  • RESULTS: The study was halted because it was unlikely to reach the primary endpoint of a favorable outcome 90 days in aneurysmal subarachnoid hemorrhage (aSAH) patients. EG-1962-treated patients had a similar favorable outcome to placebo patients using the extended Glasgow outcome scale [eGOS] scale.
  • Mayer's Abstract (new window)
  • Mayer's Presentation Slides (PDF)

Greater Exercise Dose During Stroke Inpatient Rehabilitation Improves Walking Recovery, but the Response is Not Linear
Tara D Klassen | University of British Columbia, Vancouver, BC, Canada

Friday's Selected Science


The Paola DeRango Memorial Session | Women in Stroke

Moderators Stacie Demel, DO, PhD and Dawn Kleindorfer, MD, discuss the topics planned for The Paola DeRango Memorial Session | Stroke in Women Throughout the Life Course: An International Perspective and why research on stroke in women specifically is so important.


ISC 2019: What We Learned

Louise McCullough, MD, PhD reviews the top science presented for ISC 2019, including MISTIE III and SHINE, and encourages viewers to attend ISC 2020 in Los Angeles next year.

Extending the Thrombolytic Time Window to 9 Hours for Acute Ischemic Stroke Using Perfusion Imaging Selection - The Final Result
Henry Ma | Monash University, Clayton, Australia

  • RESULTS: This trial was stopped early. Using perfusion imaging selection in AIS patients presenting 4.5-9 hours from stroke onset or with a wake-up stroke were selected to receive either alteplase or placebo. Better functional outcome at 3 months was noted in the alteplase group.
  • Ma's Abstract (new window)
  • Ma's Presentation Slides (PDF)

Intracerebral Hemorrhage Deferoxamine (iDEF) Trial: Main Results
Magdy H Selim | Beth Israel Deaconess Medical Center, Boston, MA

Telerehabilitation in the Home versus Therapy In-Clinic for Patients With Stroke
Steven C Cramer | University of California Irvine, Orange, CA