Vascular Discovery: From Genes to Medicine Scientific Sessions 2021

#VascularDiscovery21

AHA's Science News coverage brings you insights into selected presentations from this year's virtual conference held September 22-24, 2021. Find exclusive interviews, simultaneous publications, and more – all in one place.

Jump to a single day's selected science:

Wednesday  | Thursday  |  Friday

Wednesday's selected science

 

Vascular Discovery 2021 Program Highlights

Conference Chair Lars Maegdefessel and Vice-Chair Katey Rayner highlight some of the top science and featured events they have planned for Vascular Discovery 2021.

Vascular Complications of COVID-19

Participants discuss the key take-away messages from the science presented in the opening plenary session for Vascular Discovery 2021, which focused on the impact of the virus and how the effort to identify who and when to treat is transforming vascular research and clinical trials.

Moderators include Naomi M Hamburg, MD and Pradeep Natarajan, MD, MSc; the panelists are Anna Randi, MD, PhD, Yogendra Kanthi, MD, and Clyde W. Yancy, MD, MSc.

Emerging Scientist Award for Women Competition

 

Fathima Nafrisha Cassim Bawa | Kent State University, Kent, OHRetinoic Acid Receptor Alpha (Rarα) In Macrophages Protects From Diet-induced Atherosclerosis In Mice
Fathima Nafrisha Cassim Bawa | Kent State University, Kent, OH

Presentation Details (Bawa)

 

Melody Chemaly | Karolinska Institute, Solna, SwedenProprotein Convertase Subtilisin/kexin Type 6 (PCSK6) Is Involved In Regulation Of Vasculogenesis
Melody Chemaly | Karolinska Institute, Solna, Sweden

Presentation Details (Chemaly)

 

Alicia S. Eustes, University of Iowa, Iowa City, IAHistone-mediated Platelet Activation And Microvesicle-induced Thrombin Generation In COVID-19
Alicia S. Eustes | University of Iowa, Iowa City, IA

Presentation Details (Eustes)

Mariana M. Suarez | Massachusetts Institute of Technology, Cambridge, MASex Differences In Mortality And 30-day All Cause Readmission Following Carotid Endarterectomy Following Acute Ischemic Stroke: A Nsqip Study (2014 - 2017)
Mariana M Suarez | Massachusetts Institute of Technology, Cambridge, MA

Presentation Details (Suarez)

Tanyaporn Pattarabanjird, University of Virginia, Charlottesvile, VAWINNER
Single Cell Profiling Identifies IgM To MDA-LDL Producing Human B Cells And Atheroprotective Role Of CD24

Tanyaporn Pattarabanjird | University of Virginia, Charlottesville, VA

Presentation Details (Pattarabanjird)

ATVB Investigator in Training Award Competition

Mabruka Alfaidi | LSU Health Sciences CenterWINNER
The Signaling Roles Of The Adaptor Protein Nck1 In Atherosclerosis

Mabruka Alfaidi | LSU Health Sciences Center, New Orleans, LA

Presentation Details (Alfaidi)

 

Junedh M. Amrute, Washington University School of MedicineMulti Omic Atlas Of Human Coronary Artery Disease
Junedh M Amrute | Washington University School of Medicine in St. Louis, Saint Louis, MO

Presentation Details (Amrute)

 

Rolando A. Cuevas | University of PittsburghTelomerase Reverse Transcriptase Mediates Osteogenesis In Calcific Aortic Valve Disease
Rolando A Cuevas | University of Pittsburgh, Pittsburgh, PA

Presentation Details (Cuevas)

 

Adil Rasheed, Ottawa Heart Institute, Ottawa, ON, CanadaMLKL (Mixed Lineage Kinase Domain-like Protein) Is A Novel Regulator Of The Splenic Microenvironment That Restricts Hematopoiesis During Atherosclerosis
Adil Rasheed | Ottawa Heart Institute, Ottawa, ON, Canada

Presentation Details (Rasheed)

Other Science of Interest

Platelet-Induced Neutrophil Extracellular Traps Drive Ischemic Stroke Brain Injury
Frederik Denorme | University of Utah, Salt Lake City, UT

Thursday's selected science

 

Novel Concepts of Atherosclerosis

Participants discuss the key take away messages from this plenary session for Vascular Discovery 2021, which focused on new approaches for understanding the pathophysiology of atherosclerosis that can potentially be leveraged to better identify and treat risk factors for the disease. The speaker is Cristen Willer, PhD, University of Michigan Medical School; the session moderators are Esther Lutgens, MD, PhD, Amsterdam University Medical Center and Katey Rayner, PhD, University of Ottawa Heart Institute.

Winner: Emerging Scientist Award for Women Competition

Vice-Chair of the ATVB Women's Leadership Committee Hanrui Zhang, MB, PhD interviews Tanyaporn Pattarabanjird about the award-winning research topic she presented during yesterday's competition, "Single Cell Profiling Identifies IgM To MDA-LDL Producing Human B Cells and Atheroprotective Role of CD24."

 

Kenneth M. Brinkhous Young Investigator Prize in Thrombosis Competition

Joseph Aslan, Oregon Health and Science University, Portland, ORQuantitative Phosphoproteomics And Causal Analysis Reveal Distinct And Combinatorial Signaling Mechanisms In Protease-Activated Receptor PAR1 And PAR4 Platelet Activation Programs
Joseph Aslan | Oregon Health & Science University, Portland, OR

Presentation Details (Aslan)

 

WINNER
Platelets Amplify Endotheliopathy In Covid-19

Tessa J Barrett, NYU School of Medicine, New York, NY

Presentation Details (Barrett)

 

Steven P. Grover, University of North Carolina-Chapel Hill, Chapel Hill, NCC1 Esterase Inhibitor Functions As An Anticoagulant In Human And Murine Venous Thrombosis
Steven P Grover | University of North Carolina-Chapel Hill, Chapel Hill, NC

Presentation Details (Grover)

 

Abhishek Jain | Texas A&M University, College Station, TXVein-Chip Is A New Experimental Model To Predict Pathophysiology Of SARS-CoV-2 Induced Thrombosis
Abhishek Jain | Texas A&M University College Station, TX

Presentation Details (Jain)

Irvine H. Page Junior Faculty Research Award Competition

 

Julius Decano | BWH and Harvard Medical School, Boston, MAExamining The Heterogeneity Of Primary Human Macrophages And Pharmacogenomic Networks To Identify Novel Targets For Precision Medicine For Vascular Inflammation
Julius Decano | BWH and Harvard Medical School, Boston, MA

Presentation Details (Decano)

 

Clint L. Miller | University of Virginia School of Medicine, Charlottesville, VACell-specific Chromatin Landscape Of Human Coronary Artery Resolves Mechanisms Of Disease Risk
Clint L Miller | University of Virginia, Charlottesville, VA

 

Rebecca A. Porritt | Cedars Sinai Medical Center, Los Angeles, CASingle-cell and Spatial Transcriptomics Reveal An IL-1β Mediated VSMC Phenotypic Switch During Vasculitis and Cardiovascular Inflammation
Rebecca A Porritt | Cedars Sinai Medical Center, Los Angeles, CA

Presentation Details (Porritt)

 

Bhama Ramkhelawon | NYU Medical Center, New York, NYWINNER
Microskeletal Stiffness Promotes Aortic Aneurysm By Sustaining Pathological Vascular Smooth Muscle Cell Mechanosensation Via Piezo1

Bhama Ramkhelawon, NYU Medical Center, New York, NY

Presentation Details (Ramkhelawon)

Friday's selected science

 

#VascularDiscovery21 Distinguished Lecturer Marlene Rabinovitch

Kerry-Anne Rye, chair of the council on Arteriosclerosis, Thrombosis, and Vascular Biology, interviews this year's Distinguished Lecturer about her topic, "Converging Pathways in Pulmonary Vascular Pathobiology" where she describes some of the  multiple approaches she has used to identify a therapeutic target for treating pulmonary hypertension.

2021 Irvine H. Page Junior Faculty Research Award Competition Winner Bhama Rahmkhelawon

Daisy Sahoo, chair of the Irvine H. Page Award committee, interviews Bhama Ramkhelawon about the award-winning science she presented during yesterday's competition, "Microskeletal Stiffness Promotes Aortic Aneurysm by Sustaining Pathological Vascular Smooth Muscle Cell Mechanosensation Via Piezo1." They talk about Dr. Ramkhelawon's non-traditional career path, the inspiration for her work, the importance of the AHA and the ATVB council to her career development, and advice for early career scientists.

Science Highlights from #VascularDiscovery21

Conference Chair Lars Maegdefessel, MD, PhD passes the torch to Conference Vice-Chair Katey Rayner, PhD as they review the top science and featured events of this year's meeting.