Jil C. Tardiff, MD, PhD - Biographical Sketch

Dr. Tardiff is a Professor of Biomedical Engineering, Medicine and Cellular and Molecular Medicine at the University of Arizona College of Medicine and has been a practicing cardiologist for over 20 years. She holds the Steven M. Gootter Endowed Chair for the Prevention of Sudden Cardiac Death and is the Director of the Banner University Hospital – Tucson Hypertrophic Cardiomyopathy Clinic.

Dr. Tardiff’s primary expertise is in the molecular pathogenesis of hypertrophic cardiomyopathy and she has developed an integrative platform encompassing computational approaches coupled to high resolution spectroscopy, single myocyte physiology and transgenic murine models of genetic cardiomyopathies to delineate novel targetable pathways to help manage this complex disorder. Her work has formed the basis of ongoing clinical trials to assess the efficacy of calcium channel blockade and improving energy utilization in patients with preclinical hypertrophic cardiomyopathy. More recently her group has focused on the rational design of novel disease modulators based on high resolution structure and protein dynamics and the role of isoform switching and myofilament Ca2+ kinetics in the progression of genetic HCM and DCM. Her program has been continuously funded by the NHLBI since 2002 and during that time Dr. Tardiff has personally mentored 17 PhD students. Dr. Tardiff has held national leadership positions at the American Heart Association and the International Society for Heart Research, is currently an Associate Editor of Circulation Research and has served on numerous NIH study sections including chartered memberships on both Cardiac Contractility and Heart Failure and Myocardial Ischemia and Metabolism (NHLBI).