Keynote Synopsis: The Role of Innate Inflammation in Cardiac Injury and Repair
Both innate and adaptive immune responses are activated in the heart in response to tissue injury that occurs in response to pathogens or environmental injury. Whereas the innate immune system provides a global, nonspecific defense against pathogens or tissue injury, the adaptive immune system provides a highly specific response that is mediated by B and T cells. Studies have shown that the ensuing inflammatory response induced by the innate immune system can be physiological and result in the upregulation of a portfolio of cytoprotective responses that provide the heart with a short-term adaptation to the stress. Alternatively, the inflammatory response can become dysregulated (i.e., pathophysiologic), leading to collateral myocardial damage that eventuates in progressive LV dysfunction and adverse LV remodeling. This talk will focus on the role in the innate immune response in mediating tissue injury and repair, and will highlight recent studies that implicate an essential role for macrophages and B lymphocytes in mediating tissue injury and repair.