Science News
Hypertension 2019 Scientific Sessions
New Orleans Marriott | New Orleans, Louisiana
Thursday, Sept. 5
Hypertension 2019 program highlights
Curt Sigmund, PhD, chair of the Council on Hypertension Scientific Sessions Planning Committee and Jan Basile, MD, vice chair of Clinical Programs, preview some of the science they have planned for the program at this year's meeting in New Orleans.
Attendees gather in New Orleans
By all accounts, this year's Hypertension Scientific Sessions is off to a great start, with cardiovascular professionals from all over the world in attendance. See photos from this year's conference(link opens in new window).
Early and Late Post-Kidney Transplant Hypertension and Late Renal Allograft Outcome
Ekamol Tantisattamo | University of California Irvine School of Medicine, Orange, CA
- RESULTS: One month after a kidney transplant is a good time to check BP levels. Too liberal or tight BP control in normotensive or hypertensive patients at that point may worsen long-term allograft outcomes.
- Tantisattamo's Abstract (opens in new window) (link opens in new window)
Intensity of Hypertensive Exposure in Young Adulthood and Subclinical Atherosclerosis in Middle Age
Zhenyu Xiong | Sun Yat-Sen University, Guangzhou, China
- RESULTS: When young adults suffer hypertension, the longer it persists, the greater their risk for coronary artery calcification in middle age.
- Xiong's Abstract (opens in new window)(link opens in new window)
Female Offspring of Polycystic Ovary Syndrome Rat Model Exhibit Insulin Resistance and Tendency Toward Increased Blood Pressure With Aging
Noha M. Shawky | Women’s Health Research Center, University of Mississippi Medical Center, Jackson, MS
- RESULTS: Women whose mothers had polycystic ovary syndrome may be at increased risk for hypertension and metabolic dysfunction with aging, although the mechanisms for the hypertension are not clear.
- Shawky's Abstract (opens in new window)(link opens in new window)
Genetic Polymorphisms Associated With Apparent Treatment-Resistant Hypertension in Patients With Chronic Kidney Disease
Kevin Pezeshkian | Michigan State University, East Lasing, MI
- RESULTS: Distinct genetic polymorphisms — present in chronic kidney disease patients with apparent treatment-resistant hypertension (ATRH) — may be a unique genetic signature for predisposed risk of ATRH. Further study of this marker may reveal potential therapeutic targets.
- Pezeshkian's Abstract (opens in new window)(link opens in new window)
Other stories from #Hypertension19
Study hints at hot yoga benefit for blood pressure — AHA News story
Abstract: Hot Yoga and Hypertension: Exploration of a Novel Lifestyle Intervention (opens in new window)(link opens in new window)
Stacy Hunter | Texas State University, San Marcos, TX
Pumpkin pulp, seeds lower blood pressure in rat study — AHA News story
Abstract: The Role of Pumpkin Flesh in Reducing Mean Arterial Pressure in a Genetic Rat Model for Hypertension Itinerary (opens in new window)(link opens in new window)
Soweto Thomas | Tuskegee University, Tuskegee, AL
New research suggests gut bacteria may be linked to high blood pressure and depression — AHA news release
Abstract: Gut Microbiome Governs Independent Risks for Hypertension Comorbid With Depression, Hypertension Without Depression, and Depression Without Hypertension in Human Subjects(link opens in new window)
Bruce R. Stevens | University of Florida, Gainesville, FL
High blood pressure treatment may slow cognitive decline — AHA news release
Abstract: Antihypertensive Treatment Stops Cognition Decline in Elderly Chinese With Hypertension
Shumin Rui | Columbia University, New York, NY
Role of GRK4, a Risk Factor for Hypertension, in Breast Cancer
Wei Yue | University of Virginia, Charlottesville, VA
- RESULTS: G-protein coupled receptor kinase 4 (GRK4) plays a role in promoting breast cancer proliferation; GRK4 could be a new therapeutic target for treating hypertension and breast cancer.
- Yue's Abstract (opens in new window)(link opens in new window)
- AHA News Story: Scientists find biological link between high blood pressure and breast cancer
Hypoxic Peripheral Chemoreceptor Activation Engages Sympathetic Brainstem and Hypothalamic Nuclei in Human Subjects
Darius Andreas Gerlach | German Aerospace Center, Cologne, Germany
- RESULTS: High-resolution brainstem functional magnetic resonance imaging during repeated hypoxia traces brainstem circuits engaged by peripheral chemoreceptors. This method may be relevant for CVD.
- Gerlach's Abstract (opens in new window)(link opens in new window)
Carotid Body Ablation of TRPV1 Reduces Chemoreflex Sensitivity in Rats With Heart Failure
Sharon D.B. de Morais | University of Nebraska Medical Center, Omaha, NE
- RESULTS: Applying resiniferatoxin (RTX) to the carotid body of rats with heart failure (HF) reduced chemoreflex sensitivity, indicating an important role for TRPV1 signaling in chemoreflex function in HF.
- Morais's Abstract (opens in new window) (link opens in new window)
Association of Central Arterial Stiffness With Hippocampal Blood Flow, N-Acetyl Aspartate and Anxiety in Hypertensive Dahl Salt Sensitive Rats
Samuel Ajamu | National Institute on Aging, Baltimore, MD
- RESULTS: Hypertension and CVD may contribute to dementia and Alzheimer’s disease. Arterial stiffness may reduce cerebral blood flow (CBF); higher CBF is associated with lower anxiety.
- Ajamu's Abstract (opens in new window)(link opens in new window)
Hypertension Early Career Oral Award Finalists
WINNER!
Gene Editing Yields a Novel Rat Model of Cardiometabolic Disease (abstract opens in new window)(link opens in new window)
Karen C Clark, Medical College of Wisconsin, Milwaukee, WI
High Protein Diet-Induced Glomerular Hyperfiltration is Dependent on NOS1β (abstract opens in new window)(link opens in new window)
Jin Wei | University of South Florida, Tampa, FL
Sex Differences in the Development of Age-Dependent Hypertension and the Salt Sensitivity of Blood Pressure (abstract opens in new window)(link opens in new window)
Franco J Puleo | Boston University School Medicine, Boston, MA
Racial Differences in Length of Stay and Hospital Expenses in Hypertension and Pregnancy (abstract opens in new window)(link opens in new window)
Michael Z Grzeskowiak | University of Texas Health Science Center at San Antonio, San Antonio, TX
Epigenome Wide Association Study Identifies DNA Methylation Sites Associated With Target Organ Damage in Elderly African Americans (abstract opens in new window)(link opens in new window)
Farah Ammous | University of Michigan, Ann Arbor, MI
WINNER!
High Sodium Intake Induces a Catabolic State via Glomerular Hyperfiltration and Enhanced Glomerulotubular Balance in Essential Hypertension (abstract opens in new window)(link opens in new window)
Giacomo Rossitto | University of Glasgow, Glasgow, United Kingdom
Other stories from #Hypertension19
High blood pressure affects young, healthy medical students - AHA news release
Abstract: American Medical Students Have a Higher Prevalence of Stage 2 Hypertension Than the General Public: A Cross Sectional Study (opens in new window)(link opens in new window)
Jacek Bednarz Jr | Lincoln Memorial Univ, Harrogate, TN
Saturday, Sept. 7
George Bakris – 2019 Irvine Page Alva Bradley Lifetime Achievement Award Winner
Karen Griffin, MD, chair of the Council on Hypertension, interviews this year's Irvine Page & Alva Bradley Lifetime Achievement Award winner, George Bakris, MD, MA.
Hypertension 2019 Trainee Advocacy Mixer
The year's Trainee Advocacy Mixer was a big success! Attendees enjoyed spectacular views, great music, and the chance to make professional connections. See more photos from the mixer and the rest of the conference(link opens in new window).
Interplay Between Nox5 and Endoplasmic Reticulum Stress Regulates Vascular Signalling in Human Hypertension
Livia L Camargo | University of Glasgow, Glasgow, United Kingdom
- RESULTS: Nox5 upregulation influences vascular signaling and cytoskeleton reorganization in vascular smooth muscle cells - processes that lead to vascular dysfunction in hypertension.
- Carmago's Abstract (opens in new window)
Leptin-Thyroliberin Pathway in Left Ventricle Hypertrophy
Maia Aisicovich | Medical Research Institute IDIM, Natl Council of Scientific and Tech Research (CONICET); Buenos Aires Univ (UBA), Buenos Aires, Argentina
- RESULTS: A study revealed that the Leptin-Thyroliberin pathway is central to Leptin-induced left ventricular hypertrophy (LVH) and described direct thyrotropin-releasing hormone (TRH)-Leptin induction in heart cells.
- Aisicovich's Abstract (opens in new window)(link opens in new window)
Amplification of Systolic Blood Pressure and Pulse Pressure is Higher in Resistant Hypertensive Patients Irrespective of Blood Pressure Control
Badhma Valaiyapathi | University of Alabama at Birmingham, Birmingham, AL
- RESULTS: Patients with resistant hypertension retain a higher risk of CVD morbidity and mortality in spite of successful BP control.
- Valaiyapathi's Abstract (opens in new window)(link opens in new window)
- AHA News Release: Amplification of Systolic Blood Pressure and Pulse Pressure is Higher in Resistant Hypertensive Patients Irrespective of Blood Pressure Control (opens in new window)(link opens in new window)
Blood Pressure Variation and Renal Functional Changes in Chronic Renal Insufficiency Patients With or Without Diabetes in a Large Cohort Study
Ling Wang | Michigan State University, East Lansing, MI
- RESULTS: Renal function is worse in chronic kidney disease (CKD) patients with diabetes mellitus (DM) than non-DM CKD patients, but lowering blood pressure may improve renal function. Benefits are biggest on albuminuria in CKD patients with DM.
- Wang's Abstract (opens in new window)(link opens in new window)
Other Stories from #Hypertension19
No added dizzy episodes for adults on more intensive blood pressure-lowering treatment - AHA News Release
Abstract: The Effects of s Lower Blood Pressure Treatment Goal on Orthostatic Hypotension in Adults With Recent Stroke (opens in new window)
Stephen P Juraschek, BIDMC-Harvard Medical Sch, Auburndale, MA
Native Hawaiians lowered blood pressure with hula dancing - AHA News Release
Abstract: A Cultural Dance Program Proves Efficacious for Hypertension Control: A Randomized Controlled Trial (opens in new window)(link opens in new window)
Joseph Keawe'aimoku Kaholokula | University of Hawaii, Honolulu, HI
Mitochondrial Fission in Vascular Cells Mediates Hypertensive Vascular Remodeling and Inflammation
Hannah Cooper | Temple University, Philadelphia, PA
- RESULTS: Inhibition of mitochondrial fission prevents angiotensin II-induced CV remodeling and inflammation by attenuating vascular smooth muscle cells and endothelial cell signaling events.
- Cooper's Abstract (opens in new window(link opens in new window))
Sex-Differences in Fetal Programming of Cardiomyopathy Induced by Hypertensive Disorders of Pregnancy in Mice
Mariane Bertagnolli | CIUSSS Nord-de-l'Île-de-Montréal, Montréal, QC, Canada
- RESULTS: A study validated a new ultrasound imaging protocol to describe sex-differences in the fetal programming of cardiomyopathy in a genetic mice model of maternal hypertension and superposed pre-eclampsia. It showed that fetal cardiac remodeling changes persisted into adulthood in offspring of hypertensive mothers.
- Bertagnolli's Abstract (opens in new window)(link opens in new window)