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Strategically Focused Research Network Awardees

The AHA is currently funding five Strategically Focused Research Networks:

  • Northwestern University (Ill.), Vanderbilt University (Tenn.), Icahn School of Medicine at Mount Sinai (N.Y.), and the University of Texas, Southwestern (Texas), form the Strategically Focused Prevention Research Network.
  • The University of Iowa (Iowa), the Medical College of Wisconsin (Wis.), Cincinnati Children's Hospital (Ohio), and the University of Alabama, Birmingham (Ala.) form the Strategically Focused Hypertension Research Network.
  • Medical University of South Carolina (S.C.), Morehouse School of Medicine (Ga.), Northwestern University (Ill.), and the University of Colorado Denver (Colo.) form the Strategically Focused Disparities in Cardiovascular Disease Research Network.
  • Columbia University Medical Center (N.Y.), Johns Hopkins University School of Medicine (Md.), Magee-Womens Research Institute and Foundation (Pa.), New York University Medical Center (N.Y.), and the University of California, San Diego (Calif.) from the Go Red For Women Research Network.
  • Duke University Medical Center (N.C.),  Massachusetts General Hospital (Mass.), University of Utah (Utah), University of Colorado Denver (Colo.) from the Strategically Focused Heart Failure Research Network. 

Strategically Focused Heart Failure Research Network

Award Activation: July 1, 2016


Duke University Medical Center

Center Director: Gary Felker, MD, MHSc
Training Director: Joseph Rogers, MD
Basic
Project PI: Svati Shah, MD, MS
Branched Chain Amino Acid and other Metabolic Pathways in Diabetic Heart Failure
Clinical
Project PI: Gary Felker, MD, MHSc
A randomized trial of a mobile health behavioral intervention in patients with heart failure and diabetes mellitus Population Project PI: Adrian Hernandez, MD Improving Population Health for Patients with Diabetes and Heart Failure (IMPAcT-HF)
Population
Project PI: Adrian Hernandez, MD
Improving Population Health for Patients with Diabetes and Heart Failure (IMPAcT-HF) 


Massachusetts General Hospital

Center Director: Anthony Rosenzweig, MD
Training Director: Marc Semigran, MD
Basic
Project PI: Anthony Rosenzweig, MD
Functional roles of circulating ncRNAs in pathological hypertrophy and heart failure
Clinical
Project PI: Saumya Das, MD
Extracellular RNAs as Mediators of Cardiac Remodeling in Human Heart Failure
Population
Project PI: Jane Freedman, MD
Extracellular RNA, Adverse Left Ventricular Remodeling, and Heart Failure Progression

University of Colorado, Denver

Center Director: Peter Buttrick, MD
Training Director: Peter Buttrick, MD
Basic
Project PI: Timothy McKinsey, PhD
Epigenetic Readers as Downstream Effectors of Beta1-Adrenergic Receptor Signaling in HFrEF
Clinical
Project PI: Michael Bristow, MD, PhD
Therapeutic Molecular and Structural Phenotypic Changes of Heart Rate Reduction in HFrEF 
Population
Project PI: Larry Allen, MD, MHSc
Electronic health record-leveraged, Patient-centered, Intensification of Chronic care for Heart Failure (EPIC-HF) 

University of Utah

Center Director: Craig Selzman, MD
Training Director: Dean Li, MD, PhD
Basic
Project PI: Evan Abel, MD, PhD
Coupling glucose uptake and pyruvate utilization to increase myocardial recovery in heart failure
Clinical
Project PI: Stavros Drakos, MD, PhD
Predictors of myocardial recovery in chronic heart failure
Population
Project PI: Josef Stehlik, MD, MPH
Patient-reported outcomes as an indicator of disease transitions in heart failure

Go Red For Women Research Network

Award Activation: April 1, 2016


Columbia University Medical Center

Center Director: Lori Mosca, MD, MPH, PhD, FAHA
Training Director: Anne Taylor, MD
Basic
Project PI: Sanja Jelic, MD
The Effects of Sleep Restriction on Endothelial Activation in Pre- and Post-Menopausal Women
Clinical
Project PI: Marie Pierre St-Onge, PhD, FAHA
Impact of Sleep Restriction on Cardio Metabolic Risk Factors in Pre- vs Postmenopausal Women
Population
Project PI: Brooke Aggarwal, EdD, MS, CHES
Sleep and Cardio Metabolic Risk in Different Life Stages in a Diverse Population of Women

Johns Hopkins University School of Medicine

Center Director: Pamela Ouyang, MBBS, FAHA
Training Director: Erin Michos, MD, MHS, FAHA
Basic
Project PI: David Kass, MD, FAHA
Female Sex-Hormones and Cyclic GMP-PKG Modulation of Cardiac Disease and Metabolism
Clinical
Project PI: Sanjiv Shah, MD, FAHA
Role of Female Sex and Hormone Status on HFpEF Pathophysiology and Therapy
Population
Project PI: Wendy Post, MD, MS/Dhananjay Vaidya, MBBS, PhD, MPH
Sex Differences in Hormonal and Cyclic GMP Dependent Pathways to Heart Failure with Preserved Ejection Fraction

Magee-Womens Research Institute and Foundation

Center Director: Carl Hubel, PhD
Training Director: James Roberts, MD
Basic
Project PI: Robert Powers, PhD
The Influence of Pregnancy on Future Vascular Dysfunction and Atherosclerosis
Clinical
Project PI: Carl Hubel, PhD
Glycocalyx Pathways Linking Pregnancy Profile with Microvascular Dysfunction Postpartum
Population
Project PI: Janet Catov, PhD, MS
The Placenta as a Window to Maternal Microvascular Disease Risk

New York University Medical Center

Center Director: Judith Hochman, MD, FAHA
Training Director: Glenn Fishman, MD, FAHA
Basic
Project PI: Jeffrey Berger, MD, FAHA
Comprehensive Assessment of Platelet Activity in Women with Myocardial Infarction
Clinical
Project PI: Harmony Reynolds, MD, FAHA
Mechanistic Insights into Myocardial Infarction with Non-obstructive Coronary Artery Disease (The MINOCA Study)
Population
Project PI: Tanya Spruill, PhD
Telephone-Based Stress Management for Women with Myocardial Infarction

University of California, San Diego

Center Director: Matthew Allison, MD, MPH, FAHA
Training Director: Matthew Allison, MD, MPH, FAHA
Basic
Project PI: Dorothy Sears, PhD
Mechanistic Transducers and Biomarkers of Sedentary Behavior-Associated Cardiovascular Disease Risk in Latina Women
Clinical
Project PI: Jacqueline Kerr, PhD, MSc
Randomized Control Trial to Reduce Sitting Time in Postmenopausal Latina Women at Increased Risk for Heart Disease
Population
Project PI: Sheila Castaneda, PhD
Biopsychosocial and Ecological Correlates of Latina Women's Sedentary Behavior

Strategically Focused Disparities in Cardiovascular Disease Research Network

Award Activation: July 1, 2015


Medical University of South Carolina

Center Director: Robert Adams, MD, MS
Training Director: Daniel Lackland, DrPH, FAHA
Basic
Project PI: Mark Kindy, PhD
Metabolic determinants of vascular stiffness in health disparities related stroke
Clinical
Project PI: Leonardo Bonilha, MD, PhD
Influence of pre-morbid brain health on stroke recovery
Population
Project PI: Gayenell Magwood, PhD
Community-based Intervention under Nurse Guidance after Stroke (CINGS)

Morehouse School of Medicine

Center Director: Herman Taylor Jr., MD, MPH, FACC, FAHA
Training Directors:
Gregory Strayhorn, MD, PhD
Sandra Dunbar, RN, PhD, FAAN, FAHA, FPCNA
Basic
Project PI: Charles Searles, MD, FAHA/Dean Jones, PhD
MicroRNA and metabolic profiles associated with social and environmental risk factors in blacks
Clinical
Project PIs: Arshed Quyyumi, MD/Priscilla Pemu, MBBS, MSCR, FACP
Impact of technology-based Intervention for improving self-management behaviors in Black adults
Population
Project PIs: Peter Baltrus, PhD/Tené Lewis, PhD
Social and Environmental Factors contributing to Cardiovascular Risk and Resilience among Blacks

Northwestern University

Center Director: Myles Wolf, MD, MMSc
Training Director: Clyde Yancy, MD, MSc, MACC, FAHA, MACP
Basic
Project PI: Myles Wolf, MD, MMSc
Molecular Mechanisms of Cardiac Injury Induced by FGF23 in the Settings of High Phosphate Diet and CKD
Clinical
Project PI: Orlando Gutierrez, MD, MMSc
Impact of lowering phosphate additive intake on mineral metabolism and cardiovascular health in community-living adults
Population
Project PI: Mercedes Carnethon, PhD, FAHA
Contribution of Fibroblast Growth Factor 23 to Racial Disparities in Left Ventricular Mass and Albumin/Creatinine Ratio

University of Colorado Denver

Center Director: Spero Manson, PhD
Training Director: Spero Manson, PhD
Basic
Project PI: Irene Blair, PhD
Discrimination and Allostatic Load Among American Indians
Clinical
Project PI: Edward Havranek, MD
An Intervention to Increase Engagement with Hypertension Care for American Indian Patients
Population
Project PI: John Steiner, MD, MPH
Improving Hypertension Care of American Indians and Alaska Natives through Interactive Voice Response Technology

Strategically Focused Hypertension Research Network

Award Activation: April 1, 2015


Cincinnati Children's Hospital

Center Director: Elaine Urbina, MD, MS, FAHA
Training Director: Mark Mitsnefes, MD
Basic
Project PI: Richard Becker, MD, FAHA
Influence of Regulatory Genome on Target Organ Damage in Youth with Primary Hypertension
Clinical
Project PI: Joseph Flynn, MD, MS
Hemodynamic and Metabolic Predictors of Target Organ Damage in Youth with Primary Hypertension
Population
Project PI: Elaine Urbina, MD, MS, FAHA
Threshold for Development of Blood Pressure-Related Target Organ Damage in Youth

Medical College of Wisconsin

Center Director: Mingyu Liang, MB, PhD
Training Director: Allen W. Cowley, Jr., PhD
Basic
Project PI: David L. Mattson, PhD, FAHA
Epigenetic Modification of Immune Mechanisms in Salt-Sensitive Hypertension and Renal Damage
Clinical
Project PI: Srividya Kidambi, MD, MS
Epigenomics of Hypertension in Monozygotic Twins and Effect of Salt Intake
Population
Project PI: Theodore A. Kotchen, MD, FAHA
Epigenomic Modifications in Hypertension and Hypertension-Related Cardiovascular Diseases

University of Alabama at Birmingham

Center Director: Paul Muntner, PhD, MHS
Training Director: Suzanne Oparil, MD, FACC, FAHA, FASH
Basic
Project PI: Jennifer Pollock, PhD, FAHA
Novel Mechanisms of Salt-sensitivity and Diurnal Blood Pressure Rhythm
Clinical
Project PI: David Calhoun, MD, FAHA
Mechanisms of Nocturnal Hypertension and Non-dipping Blood Pressure
Population
Project PI: Paul Muntner, PhD, MHS
Racial Differences and US population estimates of Nocturnal Hypertension and Non-dipping

University of Iowa

Center Director: Curt D. Sigmund, PhD, FAHA
Training Director: Kimberly K. Leslie, MD
Basic
Project PI: Justin L. Grobe, PhD, FAHA
Molecular Mechanisms of Vasopressin-Induced Preeclampsia
Clinical
Project PI: Gary L. Pierce, PhD
Early Vascular Dysfunction and Elevated Copeptin in Human Preeclampsia
Population
Project PI: Mark K. Santillan, MD, PhD, FACOG, FAHA
Predicting Preeclampsia via Copeptin: Underrepresented Minorities & Synergy with Other Biomarkers

Strategically Focused Prevention Research Network

Award Activation: July 1, 2014


Icahn School of Medicine at Mount Sinai

Center Director: Valentin Fuster, MD, PhD, FAHA
Training Director: Roger Hajjar, MD, FAHA
Basic
Project PI: Eric Schadt, PhD
Applying Cross-generation Genetic and Genomic Information to Improve Cardiovascular Disease Prevention
Clinical
Project PI: Zahi Fayad, PhD, FAHA
Two Intensive Life Style Intervention Programs in Related Caregivers of Preschool Children
Population
Project PI: Valentin Fuster, MD, PhD, FAHA
Children Heart Research Study Program

Northwestern University

Center Director: Philip Greenland, MD, FAHA
Training Director: Mercedes Carnethon, PhD, FAHA
Basic
Project PI: Lifang Hou, MD, PhD
Epigenetics of Cardiovascular Health Metrics
Clinical
Project PI: Bonnie Spring, PhD, FAHA
Health Intervention to Preserve and Promote Ideal Cardiovascular Health
Population
Project PI: Norrina Allen, PhD
Trajectories in Cardiovascular Health (CVH) Metrics and Score From Childhood through Middle-Age

University of Texas Southwestern Medical Center

Center Director: Joseph Hill, MD, PhD, FAHA
Training Director: James De Lemos, MD, PhD, FAHA
Basic
Project PI: Joseph Hill, MD, PhD, FAHA
Molecular mechanisms in the transition from cardiomyocyte hypertrophy to HFpEF
Clinical
Project PI: Benjamin Levine, MD
Novel HFpEF Prevention Strategies In High Risk Individuals: High Intensity Exercise Training Plus Omega-3 Fatty Acids
Population
Project PI: Jarrett Berry, MD, MS, FAHA
Association Between Physical Activity and Modifiable Intermediate Heart Failure Phenotypes

Vanderbilt University

Center Director: David Harrison, MD, FAHA
Training Director: Meena Madhur, MD, PhD, FACC
Basic
Project PI: David Harrison, MD, FAHA
Effect of Salt on Innate and Adaptive Immune Cells in Hypertension
Clinical
Project PI: Jens Titze, MD
Lowering Tissue Na+ Stores to Reduce Blood Pressure, Systemic Inflammation, and Metabolic Derangement in Aging Humans
Population
Project PI: Thomas Jue-Fuu Wang, MD, FAHA
Prevention of Hypertension and its Complications in a Medically-Underserved Population