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2017 Distinguished Scientist -
Stanley L. Hazen, MD, PhD, FAHA

Stanley L. Hazen, MD, PhD, FAHAStanley L. Hazen, MD, PhD, FAHA
Chair, Department of Cellular & Molecular Medicine
Lerner Research Institute
Section Head, Preventive Cardiology & Rehabilitation, Heart and Vascular Institute
Cleveland Clinic
Cleveland, Ohio

Stanley Hazen, MD, PhD, received his training at Washington University School of Medicine in St Louis, including a medical degree, PhD in Biophysical Chemistry and Molecular Biology, and clinical training in Internal Medicine with subspecialty training in Diabetes, Endocrinology and Metabolism. He has been at the Cleveland Clinic his entire professional career, where he serves both as the chair of the Department of Cellular & Molecular Medicine, Lerner Research Institute, and section head of Preventive Cardiology & Rehabilitation, Heart and Vascular Institute.

Dr. Hazen has published over 380 peer reviewed articles in both basic and clinical journals alike. He has made pioneering discoveries in atherosclerosis and inflammatory disease research that are impacting clinical practice. He made the seminal discovery linking gut microbial pathways to cardiovascular disease (CVD) pathogenesis, as well as development of both heart failure and chronic kidney disease. His comprehensive work spans from bench-to-bedside, establishes a new paradigm for understanding diet-gut microbiome-host interactions in diseases, and has spawned development of both new diagnostic tests and therapeutic approaches for the treatment and prevention of CVD and metabolic disorders.

Hazen's numerous other discoveries include defining pathways leukocytes use to generate reactive oxidants, and the functional importance of oxidation processes in CVD, macrophage recognition of senescent and apoptotic cells, modified lipoproteins, or in vivo regulation of platelet hyper-responsiveness. His studies lay the foundation for development of FDA- and EU-cleared diagnostic tests for CVD risk assessment in use worldwide, and have helped to spawn pharmaceutical development of myeloperoxidase inhibitors, which are in clinical trials.

Dr. Hazen has received numerous awards, including election as member or fellow to the American Federation for Medical Research (AFMR), the American Society for Clinical Investigation (ASCI), the Association of American Physicians (AAP), American Association for the Advancement of Science (AAAS), and the National Academy of Medicine.