Late Breaking Clinical Trials from Scientific Sessions 2015

Nov. 7-11 | Orlando, FL


Science News: Late Breaking Clinical Trials

Some of the material below may be embargoed; please check back throughout the day to see presentations and material as they are released.

Each Late Breaking Clinical Trial listed below features a Summary Slide - a one-page condensed version of the study's findings.


WEDNESDAY, NOV. 11 – 10:45 AM to 12:15 PM

LBCT.04 - Novel Therapies for Common Problems

One Year Follow-up Results From AUGMENT-HF: A Multicenter Randomized Controlled Clinical Trial of the Efficacy of Left Ventricular Augmentation With Algisyl-LVR in the Treatment of Heart Failure

Douglas L Mann | Washington University School of Medicine, Barnes Jewish Hospital, St Louis, MO

Abstract (PDF) | Presentation Slides (PDF) | Discussant Slides (PDF) | Summary Slide (PDF)

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The-First-in-Man Randomized Trial of a β3-adrenoceptor Agonist in Chronic Heart Failure - The BEAT-HF Trial

Henning Bundgaard | National University Hospital, Rigshospitalet, Copenhagen, Denmark

Abstract (PDF) | Presentation Slides (PDF) | Discussant Slides (PDF) | Summary Slide (PDF)

Prevention of Cardiac Dysfunction During Adjuvant Breast Cancer Therapy (PRADA): Primary Results of a Randomized, 2 x 2 Factorial, Placebo-Controlled, Double-Blind Clinical Trial

Geeta Gulati | Akershus University Hospital, Lorenskog, Norway

Abstract (PDF) | Presentation Slides (PDF) | Discussant Slides (PDF) | Summary Slide (PDF)

ANNEXA™-R Part 2: A Phase 3 Randomized, Double-Blind, Placebo-Controlled Trial Demonstrating Sustained Reversal of Rivaroxaban-Induced Anticoagulation in Older Subjects by Andexanet Alfa (PRT064445), a Universal Antidote for Factor XA (FXA) Inhibitors

Mark Crowther | McMaster University, Hamilton, ON, Canada

Abstract (PDF) | Presentation Slides (PDF) | Discussant Slides (PDF) | Summary Slide (PDF)

Prevention of Acute Kidney Injury by Nitric Oxide During and After Prolonged Cardiopulmonary Bypass. A Double Blind Randomized Controlled Trial

Lorenzo Berra | Massachusetts General Hospital, Harvard Medical School, Boston, MA

Abstract (PDF) | Presentation Slides (PDF) | Discussant Slides (PDF) | Summary Slide (PDF)

A Randomized, Placebo Controlled Trial of Late Na Channel Inhibition (ranolazine) in Coronary Microvascular Dysfunction (CMD): Impact on Angina and Myocardial Ischemia

Noel C Bairey-Merz | Cedars-Sinai Heart Institute, Los Angeles, CA

Abstract (PDF) | Presentation Slides (PDF) | Discussant Slides (PDF) | Summary Slide (PDF)

ALN-PCSsc, an RNAi Investigational Agent That Inhibits PCSK9 With Potential for Effective Quarterly or Possibly Bi-Annual Dosing: Results of Single-Blind, Placebo-Controlled, Phase 1 Single-Ascending Dose (SAD), and Multi-Dose (MD) Trial in Adults With Elevated LDL-C, on and off Statins


Kevin Fitzgerald | Alnylam Pharmaceuticals, Cambridge, MA

Abstract (PDF) | Presentation Slides (PDF) | Discussant Slides (PDF) | Summary Slide (PDF)

Previously released science:

SUNDAY, NOV. 8

LBCT.01 - Failure is Not an Option: New Drugs and Systems of Care

Review of the State of HF

Mariell Jessup | Philadelphia, PA

Presentation slides (PDF)

A Randomized Trial of Liraglutide for High-Risk Heart Failure Patients with Reduced Ejection Fraction

Kenneth B Margulies | University of Pennsylvania, Philadelphia, PA

Abstract (PDF) | Presentation Slides (PDF) | Summary Slide (PDF)

Nitrate's Effect on Activity Tolerance in Heart Failure with Preserved Ejection Fraction (NEAT-HFpEF)

Margaret M Redfield | Mayo Clinic & Foundation, Rochester, MN

Abstract (PDF) | Presentation Slides (PDF) | Summary Slide (PDF) | Simultaneous Publication in NEJM

Oral sGC Stimulator Vericiguat in Patients with Worsening Chronic Heart Failure and Reduced Ejection Fraction - The SOluble guanylate Cyclase stimulatoR in heArT failurE patientS with REDUCED EF (SOCRATES-REDUCED) Study

Mihai Gheorghiade | Northwestern University, Chicago, IL

Abstract (PDF) | Presentation Slides (PDF) | Summary Slide (PDF) | Simultaneous Publication in JAMA

Remote Patient Management After Discharge of Hospitalized Heart Failure Patients: The Better Effectiveness After Transition - Heart Failure Study

Michael K Ong | UCLA, Los Angeles, CA

Abstract (PDF) | Presentation Slides (PDF) | Summary Slide (PDF)

Chronic Oral Study of Myosin Activation to Increase Contractility in Heart Failure(COSMIC-HF): Final Results from a Double-blind, Randomized, Placebo-controlled, Multicenter Study

 

John R Teerlink | San Francisco Veterans Affairs Medical Center and School of Medicine, University of California, San Francisco, San Francisco, CA

Abstract (PDF) | Presentation Slides (PDF) | Summary Slide (PDF)

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Where We Are, Where We Need to Go

Michel Komajda | Paris, France

Presentation Slides (PDF)

MONDAY, NOV. 9

LBCT.05 - SPRINT Trial Results: Latest News in Hypertension Management

What Else Will We Learn from SPRINT?

David Reboussin | Winston-Salem, NC

Presentation Slides (PDF)

What Remains Unanswered and Where Do We Go From Here?

Daniel W Jones | Jackson, MS

Presentation Slides (PDF)

LBCT.02 - Decreasing the Global Burden of Disease: Breakthroughs in Prevention

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Decreasing the Global Burden of Cardiovascular Disease: Moving the Needle

Tom Gaziano | Boston, MA

Presentation Slides (PDF)

The Efficacy and Safety of Varenicline, a Selective Alpha4beta2 Nicotinic Receptor Partial Agonist, for Smoking Cessation in Patients Hospitalized with Acute Coronary Syndrome: A Randomized Controlled Trial

Mark J Eisenberg | Jewish General Hospital / McGill University, Montreal, QC, Canada

Abstract (PDF) | Presentation Slides (PDF) | Summary Slide (PDF)

Impact of a Comprehensive Lifestyle Peer-group-based Intervention on Cardiovascular Risk Factors: A Randomized Controlled Trial

Valentin Fuster, Icahn School of Medicine at Mount Sinai, New York, NY

Abstract (PDF) | Presentation Slides (PDF) | Summary Slide (PDF) | Simultaneous Publication in | JACC

Clinical Trial of a Mobile Health Intervention for Simultaneous versus Sequential Diet and Activity Change

Bonnie Spring | Northwestern University, Chicago, IL

Abstract (PDF) | Presentation Slides (PDF) | Summary Slide (PDF)

The Effect of Disclosing Genomic Risk of Coronary Heart Disease on Low-density Lipoprotein Cholesterol Levels: The Myocardial Infarction Genes (MI-GENES) Study

Iftikhar J Kullo | Mayo Clinic, Rochester, MN

Abstract (PDF) | Presentation Slides (PDF) | Summary Slide (PDF)

Empagliflozin and Cardiovascular Outcomes in Patients with Type 2 Diabetes Mellitus at High Cardiovascular Risk

Silvio E Inzucchi | Yale University School of Medicine, New Haven, CT

Abstract (PDF) | Presentation Slides (PDF) | Summary Slide (PDF)

SS.04 - Artificial Hearts: Lasker Awardee Lecture

The Artificial Hearts

Alain Carpentier, Paris, France

Presentation Slides (PDF)

LBCT.06 - Two Year Clinical Update: CT Surgery Network Severe MR Trial

Two-Year Outcomes Following Mitral Valve Repair or Replacement for Severe Ischemic Mitral Regurgitation

Daniel Goldstein | Montefiore Medical Center, Bronx, NY

Abstract (PDF) | Presentation Slides (PDF) | Summary Slide (PDF)| Simultaneous Publication in | NEJM

TUESDAY, NOV. 10 – 10:45 AM to 12:15 PM

LBCT.03 - ACS and PCI: The Continuum of Care

Providing Rapid Out of Hospital Acute Cardiovascular Treatment (PROACT-4)

Justin A Ezekowitz | University of Alberta, Edmonton, AB, Canada

Abstract (PDF) | Presentation Slides (PDF) | Discussant Slides (PDF) | Summary Slide (PDF)

Clinical Outcomes of Intravascular Ultrasound Guided Everolimus-Eluting Stents Implantation in Long Coronary Lesions

Myeong-Ki Hong | Severance Cardiovascular Hospital and Cardiovascular Research Institute, Yonsei University College of Medicine, Seoul, Republic of Korea

Abstract (PDF) | Presentation Slides (PDF) | Discussant Slides (PDF) | Summary Slide (PDF) | Simultaneous Publication in | JAMA

Long-Term Tolerability of Ticagrelor in the PEGASUS-TIMI 54 Trial

Marc P Bonaca | Brigham and Women's Hospital, Boston, MA

Abstract (PDF) | Presentation Slides (PDF) | Discussant Slides (PDF) | Summary Slide (PDF)

Individualizing Treatment Duration of Dual Antiplatelet Therapy After Percutaneous Coronary Intervention: An Analysis of the DAPT Study

Robert W Yeh | Harvard Medical School, Boston, MA

Abstract (PDF) | Presentation Slides (PDF) | Discussion Slides (PDF) | Summary Slide (PDF)

Angina and Quality of Life Following PCI with Incomplete Revascularization: Results From the Ranolazine for Incomplete Vessel Revascularization (RIVER-PCI) Trial

Karen P Alexander | Duke Clinical Research Institute, Durham, NC

Abstract (PDF) | Presentation Slides (PDF) | Discussion Slides (PDF) | Summary Slide (PDF) | Simultaneous Publication in | Circulation

STEMI/PCI Guidelines

Patrick T O'Gara, Boston, MA

Presentation Slides (PDF)