Science News from BCVS 2017

Basic Cardiovascular Sciences Scientific Sessions

July 10 – 13, 2017
Hilton Portland | Portland, Oregon

Jump to one day's coverage:  Monday  Tuesday  Wednesday  Thursday

Other important links:  Online Program Planner    |    BCVS 2017 Abstracts (6MB) (PDF) | BCVS 2017 Final Program (PDF)   |   BCVS 2017 ePosters

Selected Science from Monday, July 10


BCVS 2017 Program Highlights

John Warner, MD, president of the American Heart Association, interviews BCVS 2017 program committee co-chairs Michael Kapiloff, MD, PhD, Rong Tian, MD, PhD, and Jennifer Van Eyk, PhD.


Early Career "Next Best Thing" Session

Moderators Jop van Berlo, MD, PhD and Susmita Sahoo, PhD recap the science presented during the Early Career Pre-Conference session on the "Next Best Thing" in Cardiovascular Research.

Sprr2b Drives Proliferation of Cardiac Fibroblasts by Relieving p53-mediated Cell Cycle Inhibition
Ryan M Burke | University of Rochester, Rochester, NY

  • RESULTS: Sprr2b's unique role identified for development of cardiac fibrosis
  • Abstract
 

MANF, A Structurally Unique Redox-Sensitive Chaperone, Restores ER Protein Folding in the Ischemic Heart
Adrian Arrieta | San Diego State University, San Diego, CA

  • RESULTS: MANF’s function in reducing ischemic heart damage described.
  • Abstract

Loss of Type 9 Adenylyl Cyclase Triggers Reduced Phosphorylation of Hsp20 and Diastolic Dysfunction
Tanya A Baldwin | McGovern Medical School at University of Texas Health Science Center at Houston (UTHealth), Houston, TX

  • RESULTS: New roles for AC9 in cardiac function identified.
  • Abstract

MicroRNAs Mediate the Hemodynamic Regulation of Endothelium-to-Smooth Muscle Signaling
Jing Zhou | Peking University Health Science Center, Beijing, China

  • RESULTS: Identification of SNARE activation process may prove valuable for proliferative vascular diseases.
  • Abstract
  • Video Interview

 

Β-Arrestin-Biased Agonism of Β-Adrenergic Receptor Regulates Dicer-mediated MicroRNA Maturation to Promote Cardioprotective Signaling
Jian-Peng Teoh | Augusta University, Augusta, GA

  • RESULTS: Novel cardioprotective mechanism described for Β-adrenergic receptor (ΒAR) signaling.
  • Abstract

Sildenafil Inhibits Neointimal Hyperplasia After Angioplasty, and Reduces Platelet Aggregation
Han Mo Yang | Seoul National University Hospital, Seoul, Korea, Republic of


 

Cardiomyocyte CaMKII Mediates Expression of Pro-inflammatory Chemokines and Cytokines, Macrophage Infiltration and Cardiac Remodeling in Response to Pressure
Takeshi Suetomi | Department of Pharmacology, University of California, San Diego, School of Medicine, La Jolla, CA

  • RESULTS: CMKII's role in inflammatory response, fibrosis, and heart failure.
  • Abstract

Selected Science from Tuesday, July 11

Big Data in Cardiovascular Research

Maggie Lam, PhD interviews Karen Ross, PhD about the role of big data in cardiovascular research.


Heard at BCVS 2017: Findings from live cell imaging – an Early Career view of the "The Next Best Thing in CV Research"

Jop van Berlo, MD, PhD, interviews Alexander Froese on his presentation, "Two Different Microdomains of β1-adrenoreceptor Signaling Revealed by Live Cell Imaging."


Heard at BCVS 2017: Beneficial role for kinase-independent PI3Kγ function - an Early Career view of the "Next Best Thing in CV Research"

Susmita Sahoo, PhD, interviews Maradumane Mohan about his presentation, "Kinase-independent Function of PI3Kγ Enables ERK Activation."


 

Restoration of Impaired Diastolic Function in Hypertrophic Cardiomyopathy Induced Pluripotent Stem Cell-derived Cardiomyocytes by Re-balancing the Calcium
Haodi Wu | Stanford University, Stanford, CA

  • RESULTS: Induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) demonstrate cellular mechanism for diastolic dysfunction.
  • Abstract

 

Chromatin Organization in Diseased and Healthy Mouse Heart
Chukwuemeka George Anene Nzelu | National University of Singapore, Singapore, Singapore

  • RESULTS: 3-D chromatin structure offers first clues to genome-wide chromatin interactions, genomic compartments, and cardiac-specific gene expression.
  • Abstract

CTRP9 Regulates the Fate of Implanted Mesenchymal Stem Cells and Mobilizes Their Protective Effects Against Ischemic Heart Injury via Multiple Novel Signaling
Wenjun Yan | Thomas Jefferson University, Philadelphia, PA

  • RESULTS: CTRP9 is key to a healthy microenvironment; stem cell research in myocardial infarction may benefit from this finding.
  • Abstract

 

Tracking of CD16 Monocytes Following Delivery Into the Ischemic Limb - a Bench to Bedside Study
Ashish S Patel | King's College London, London, United Kingdom

  • RESULTS: First-in-man study finds CD16 monocytes viable in ischemic tissue, suggesting a potential future therapeutic option for patients with critical limb ischemia.
  • Abstract

Myocardial Hypertrophy and Circulating RNAs
Ravi V Shah | Massachusetts General Hospital, Boston, MA

  • RESULTS: Circulating miRNAs may provide molecular protection in the progression of myocardial hypertrophy to heart failure.
  • Abstract

 

Searching Genetic Modifiers For bag3-based Cardiomyopathy Using Adult Zebrafish Models
Yonghe Ding | Mayo Clinic, Rochester, MN

  • RESULTS: Forward mutagenesis screening strategy may help to identify genetic modifiers for cardiomyopathy.
  • Abstract

 

Sphingosine-1-Phosphate and RhoA Signaling Regulate Dynamin-Related Protein 1 and Cardiac Mitochondrial Fission
Cameron S Brand | Univ of California San Diego, La Jolla, CA

  • RESULTS: Mitochondrial fission suggests new cardioprotective pathway.
  • Abstract

Selected Science from Wednesday, July 12


Heard at BCVS 2017: Oxidized Lipids in Pulmonary HTN - an Early Career view of the "Next Best Thing in CV Research"

Jop van Berlo, MD, PhD interviews Gregoire Ruffenach about his presentation, "Causal Role of Oxidized Lipids in Pulmonary Hypertension Development," delivered for BCVS 2017 Early Career Pre-conference session.


Ensuring Reproducibility in Cardiovascular Science

Robert Carey, MD, Joseph Hill, MD, PhD, and Ivor Benjamin, MD discuss the importance of reproducibility in cardiovascular research.

New Approaches Using Human Cellular Models for Cardiac Disease

Joseph C. Wu, MD, PhD, FAHA, interviews Sean Wu, MD, PhD, and Deepak Srivastava, MD, about the science they presented in the session, "Human Cellular Models for Cardiac Disease.

Outstanding Early Career Award Finalists

AWARD WINNER

Suppressing Microtubule Detyrosination Reduces Stiffness and Improves Contractility in Human Cardiomyocytes
Benjamin L Prosser, UPenn School of Medicine, Philadelphia, PA

  • RESULTS: Early research demonstrates benefit of microtubule suppression in heart failure mechanics.
  • Abstract

 

Identification of a Major Role for Cytochrome B5 Reductase 3 in Cardiomyocyte Metabolism and Function
Adam C Straub | University of Pittsburgh, Pittsburgh, PA

  • RESULTS: Cyb5R3 plays a critical role in regulation of cardiomyocyte metabolism.
  • Abstract

 

Glucose-Mediated Remodeling of Cardiac DNA Methylation
Adam R Wende | University of Alabama at Birmingham, Birmingham, AL

  • RESULTS: Regulation of cellular function via DNA methylation in diabetic cardiomyopathy is directed by glycemic memory.
  • Abstract
Ashish Patel poster
 

CD16 Monocytes Stimulate Arteriogenesis to Salvage the Ischemic Limb
Ashish S Patel | King's College London, London, United Kingdom

  • RESULTS: Potential therapeutic role using tissue-remodeling monocytes expressing CD16 for critical limb ischemia patients.
  • Abstract
Duong T Nguyen
 

The Success of Humanizing Miniature Hearts is the Right Cannulation
Duong T Nguyen | AstraZeneca, Molndal, Sweden

  • RESULTS: Novel cannulation approach for preserving cardiac circulation may translate to humans.
  • Abstract
Sathyamangla Naga Prasad
 

Targeting Beta Adrenergic Receptor Resensitization Aids in Preservation of Receptor Function
Elizabeth E Martellli | Cleveland Clinic, Cleveland, OH
Presented by Sathyamangla V. Naga Prasad | Cleveland Clinic, Cleveland, OH

  • RESULTS: Evidence that resensitization of beta adrenergic receptors is inhibited in heart failure suggests future therapeutic targets.
  • Abstract
Xiaoyun Guo
 

TAB2 is Molecular Switch That Critically Regulates Myocardial Survival and Necroptosis
Qinghang Liu | University of Washington, Seattle, WA
Presented by Xiaoyun Guo | University of Washington, Seattle, WA

  • RESULTS: TAB2 found to be key regulator in myocardial cell death (necroptosis) and remodeling.
  • Abstract

Cardiac Activation of β-catenin in Mice Leads to Prolongation of QRS and Susceptibility to Arrhythmia by Inhibiting Na+ Channel Activity Through Suppression of NaV1.5 Expression
Rong Huo | UCLA, Los Angeles, CA

  • RESULTS: Mechanism for ?-catenin?s role in arrhythmias described in pre-clinical study.
  • Abstract
Alexander Froese poster
 

Two Different Microdomains of β1-adrenoreceptor Signaling Revealed by Live Cell Imaging
Alexander Froese | University Medical Center Hamburg, Hamburg, Germany

  • RESULTS: Location, location – different microdomains result in different signaling for cardiomyocyte β1-adrenergic receptors.
  • Abstract

Selected Science from Thursday, July 13


BCVS 2017 What We Learned

BCVS 2017 Program Co-chairs Rong Tian, MD, PhD, Jennifer Van Eyk, PhD, and Michael Kapiloff, MD, PhD review the highlights of the meeting this year in Portland, OR.


Heard at BCVS 2017: Circulating RNAs may help against HF - an Early Career view of the "The Next Best Thing in CV Research"

Susmita Sahoo, PhD interviews Ravi Shah about the science he presented for the Early Career Pre-conference session.

BCVS17 Keynote Lecturer Calum MacRae

BCVS 2017 Council Chair Ronglih Liao, PhD interviews Keynote Lecturer Calum MacRae, MD, PhD about his vision for One Brave Idea.


There were plenty of awards given at BCVS17 this year. Visit the photo gallery to download and share yours.


Presenters, experts and more shared some great ideas. Visit the photo gallery to see all the action.