Science News from BCVS 2016

Basic Cardiovascular Sciences 2016

July 18 – 21, 2016
Hyatt Regency Phoenix | Phoenix, AZ


Monday, July 18


Ronglih Liao, PhD, 2016 chair of the Council on Basic Cardiovascular Sciences, interviews Steven Houser, PhD, president of the American Heart | American Stroke Association and welcomes attendees to BCVS 2016 Scientific Sessions in Phoenix.


Ronglih Liao, PhD and Joseph Wu, MD, PhD, chair and vice chair of the council on Basic Cardiovascular Sciences, interview Brian Kobilka, MD, about his Nobel Prize winning work, his career, and his advice for early career scientists.


Attendees look at the AHA Meetings app to decide which sessions to attend on Monday.
To download the app, search "AHA Events" in the App Store or Google Play.
See and share more of AHA's #BCVS16 photos! (link opens in new window)

Stem Cell-derived Exosomes Induce Cardiac Repair via mRNA Modification
Prabhu Mathiyalagan | Icahn School of Medicine at Mount Sinai, New York, NY


Endothelial Nogo-B Regulates Sphingolipid Biosynthesis to Promote the Onset of Pathological Hypertrophy During Chronic Pressure Overload
Yi Zhang | Weill Cornell Medicine, New York, NY


The Tumor Suppressor Gene Tip30 Supports Cardiac Compensation During Overload And Inhibits Myocardial Protein Synthesis
Joerg Heineke, Medische Hochschule Hannover, Hannover, Germany


The Role of TGFβ Signaling In A Fibrotic cMyBP-C HCM/HF Model
Qinghang Meng | Cincinnati Children's Hospital Medical Center, Cincinnati, OH

Defective Branched-chain Amino Acid Catabolism Impairs Glucose Metabolism And Sensitizes The Heart To Ischemia/reperfusion Injury
Tao Li | University of Washington, Seattle, WA


Effect of Hypoxic Preconditioning on Cortical Bone Stem Cells (CBSCs)
Giulia Borghetti | Cardiovascular Research Center, Temple University, Philadelphia, PA


Yap Plays A Crucial Role In The Development Of Cardiomyopathy In Lysosomal Storage Diseases
Shohei Ideda | Rutgers New Jersey Medical School, Newark, NJ

Tuesday, July 19


Michael Davis, PhD and Susmita Sahoo, PhD, discuss the latest developments in cardiovascular exosome science presented Tuesday.


Yibin Wang, PhD, interviews Steve Houser, president of the American Heart | American Stroke Association, and Rick Kitsis, MD about the latest science on cardiac cell death and aging that was presented on Tuesday.

Tuesday's BCVS16 attendees

Attendees took careful notes during the Tuesday morning sessions at the AHA's Basic Cardiovascular Sciences conference. More than 600 attendees from 22 countries are in Phoenix. Tag your social media photos with #BCVS16.

Novel Mechanisms of Non-coding Genomic Regulation Identified in Cardiac Disease-in-a-dish Models
Aditya Kumar | University of California, San Diego, San Diego, CA


LAMP-2 Deficiency Promotes Mitochondrial Damage in Danon Disease
Sherin Hashem | University of California San Diego, La Jolla, CA


Transcriptomic Analysis of Inter- and Intra-patient Variation in Human iPSCs: Platform for Precision Medicine to Predict Drug Toxicity
Elena Matsa | Stanford University School of Medicine, Stanford, CA

IL10-inhibits Fibroblast Progenitor Cell-mediated Cardiac Fibrosis in Pressure-overloaded Myocardium
Suresh K Verma | Center for Transnational Medicine, Temple University, Philadelphia, PA


Engineering Nanomaterial Morphology for Targeting Immune Cells Within Atherosclerotic Lesions
Sijia Yi | Chemistry of Life Processes Institute, Evanston, IL


Structural Reorganization of Cardiac Transcription Factories Mediates Transcriptional Changes in Response to Stress
Elaheh Karbassi | UCLA, Los Angeles, CA

Wednesday, July 20


Sean Wu, MD, PhD and Da-Zhi Wang, PhD discuss the latest cardiac development and congenital disease science presented Wednesday at BCVS 2016.


Joseph Wu, MD, PhD, Malica Radisic, PhD, and Kevin Healy PhD discuss some of the latest disease modeling technology used in drug discovery

RELATED SCIENCE: Watch Dr. Donald Ingber, AHA's 2014 Connor Lecturer, discuss his work with organs on a chip and nanotherapy. (link opens in new window).


Joseph C. Wu, MD, PhD, FAHA, spoke Wednesday morning during Session 8 – Organ on a Chip: iPS Cells in Disease Modeling of Cardiovascular System.

Outstanding Early Career Investigator Finalists

Sadia Mohsin

WINNER

Cortical Bone Stem Cells Derived Exosomes as Potent Modulator of Cardiac Immune Response and Repair After Injury
Sadia Mohsin | Lewis Katz School of Medicine, Temple University, Philadelphia, PA

Fabrice Jaffre


Abnormal Cardiac Differentiation Underlies Cardiac Hypertrophy in Noonan Syndrome With RAF1 Mutation
Fabrice Jaffre | Beth Israel Deaconess Medical Center, Boston, MA

Junko Warren


The Histone Methyltransferase Smyd1 is a Novel Transcriptional Regulator of Cardiac Fatty Acid Metabolism in Mice
Junko S Warren | University of Utah, Salt Lake City, UT

BET Bromodomain Inhibition Blunts Heart Failure Progression and Fibrosis in Genetic Cardiomyopathy
Michael A Burke, Emory University School of Medicine, Atlanta, GA


Activated Cardiac Myofibroblasts Can Revert Back to Become Resident Fibroblasts Upon Injury Cessation
Onur Kanisicak | Children's Hospital Medical Center, Cincinnati, OH


The Pathophysiological Role of MYBPHL in Dilated Cardiomyopathy
David Y Barefield | Northwestern University, Chicago, IL

The Estrogen-Related Receptor Gamma Promotes Maturation of iPSC-derived Cardiac Myocytes
Tomoya Sakamoto | Sanford Burnham Prebys Medical Discovery Institute, Orlando, FL


Regulation of Cardiomyocyte Proliferation by the Hippo Pathway and Dystrophin Complex
Yuka Morikawa | Texas Heart Institute, Houston, TX


Leukocyte-expressed β2-adrenergic Receptors Are Essential For Survival Following Acute Myocardial Injury
Douglas Tilley | Temple University, Philadelphia, PA

Thursday, July 21, 2016


Jil Tardiff, MD interviews Josh Hare, MD and Roberto Bolli, MD about the latest developments in cardiac stem cell research that were presented Thursday.


Jay Zhang, MD, PhD, Maria Kontiridis, PhD, and Raj Kishore, PhD review some of the breakthrough science that was presented during BCVS 2016 in Phoenix.


Awardees posed during the BCVS Council dinner and awards program Thursday night. To download your picture, visit our photo site(opens in new window.) Tag your photos with #BCVS16.