Science News from ATVB|PVD 2016

Arteriosclerosis, Thrombosis and Vascular Biology | Peripheral Vascular Disease
May 6 – 7, 2016

SCIENCE NEWS provides an in-depth look at selected ground-breaking studies presented at ATVB|PVD 2016 in Nashville, Tenn. through exclusive video interviews, presentation slides, and more. Keep checking back throughout the conference for the latest information.

Thursday, May 5

Welcome to ATVB|PVD 2016


Mark Creager, MD, president of the American Heart Association, interviews Philip Tsao, PhD and Nancy Webb, PhD, the conference chair and co-chair of ATVB|PVD 2016 about what they have planned for the meeting this year.

A Decade of GWAS Studies in Cardiovascular Disease


Philip Tsao, PhD, conference chair of ATVB PVD 2016, interviews Erik Ingelsson, MD, PhD about his plenary presentation, "Ten Years and Hundreds of Novel Cardiovascular Loci: What Now?"

Developing Novel Therapies for Abdominal Aortic Aneurysm


Nancy Webb, PhD, vice chair for ATVB/PVD 2016, interviews Christine Pham, MD and John Curci, MD about current laboratory and clinical efforts to develop novel therapies for AAA.

Chinese American Academy of Cardiology at ATVB|PVD 2016


Steve Lentz, MD, PhD, vice chair of the council on ATVB, interview Hong Wang, MD, PhD, president of the Chinese American Academy of Cardiology and Eugene, Chen, MD, PhD and Ming-Hui Zou, MD, PhD, chairs of the Metabolic Vascular Disease Symposium about the organization.

Ten Years and Hundreds of Novel Cardiovascular Loci: What Now?
Erik Ingelsson | Stockholm, Sweden
Ingelsson Presentation Slides (PDF) | Ingelsson Video interview (opens in new window)

The RNA-Binding Protein ADAR2 Controls Interleukin-6-induced Endothelial Cell Proinflammatory Response By Regulating MicroRNA Biogenesis
Konstantinos Stellos | J.W. Goethe University, Frankfurt, Frankfurt am Main, Germany
Stellos Abstract (PDF)

APOC3 A43T Variant Promotes ApoC-III Catabolism and Accelerates TG-rich Lipoprotein Clearance in Mice and Humans
Sumeet A. Khetarpal | University of Pennsylvania, Philadelphia, PA
Khetarpal Abstract (PDF)

Nogo-B Controls Inflammation by Regulating Autophagy in Macrophage
Jun Yu | Yale University School of Medicine, New Haven, CT
Yu Abstract (PDF)

A Natural Repertoire of T Cells 21 Recognizing ApoB-100 is Generated Early in Life and is Progressively Depleted During Atherosclerotic Disease
Dennis Wolf | La Jolla Institute for Allergy and Immunology, San Diego, CA
Wolf Abstract (PDF)

Inflammatory Responses in Abdominal Aortic Aneurysm: Emerging Targets for Therapy?
Christine T.N. Pham, MD | Washington University School of Medicine, St. Louis, MO
Pham Presentation Slides (PDF)

The Unique Challenges of Developing Novel Therapies for Abdominal Aortic Aneurysms
John A. Curci, MD, FACS |Vanderbilt University Medical Center, Nashville, TN
Curci Presentation Slides (PDF)

Innovation to Impact: Beginning the Process
Zorina Galis, PhD, NHLBI, Bethesda, MD
Galis Presentation Slides (PDF) | Galis Video Interview (opens in new window)

Statins Have a Dose-dependent Effect on Amputation Risk and Survival in Peripheral Arterial Disease (PAD) Patients
Shipra Arya | Emory University, Atlanta, GA
Arya Abstract (PDF)

Association of the Serum Myeloperoxidase/High-Density Lipoprotein Particle Ratio and Incident Cardiovascular Events in a Multi-Ethnic Population: Observations From the Dallas Heart Study
Htet W Khine | UT Southwestern Medical Center, Dallas, TX
Khine Abstract (PDF)

MiR-1200 Differentially Modulates Plasma LDL and HDL cholesterol Levels to Reduce Hyperlipidemia and Atherosclerosis in Mice
Liye Zhou | SUNY Downstate Medical Center, Brooklyn, NY
Zhou Abstract (PDF)

Friday, May 6

Turning Discovery into Health


Mark Creager, MD, president of the American Heart Association, interviews Zorina Galis, PhD and Marc Charette, PhD of the National Heart, Lung, and Blood Institute about new initiatives for facilitating the translation of scientific discovery into new clinical treatments for improving patient health.

Towards a Better Understanding of Venous Thrombosis


Joshua A. Beckman, MD, MS, chair of the council on PVD, interview Fedor Lurie, MD, PhD about his presentation on the need to better understand the mechanisms contributing to venous thrombosis.

Next Generation Technology Bootcamps 1 & 2


Kiran Musunuru, MD, PhD, MPH and Jane Ferguson, PhD discuss how the Next Generation Technology Bootcamps on genome editing are growing at ATVB|PVD.

Kenneth M. Brinkhous Young Investigator Prize in Thrombosis Finalists


From L-R: Colin A. Kretz, Sudipta Biswas, Kyungho Kim, Jeremy P. Wood, Joseph Italiano, PhD, chair of the Brinkhous Prize Committee

Irvine H. Page Young Award Investigator Research Award Finalists


From L-R: Gabrielle Fredman, Claudia Goettsch,Rebecca Haeusler, Eric P. van der Veer, Jonathan Smith, vice chair of the Page Award Committee

Prothrombotic Role of Platelet Tlr2 40 in Hyperlipidemia
Sudipta Biswas | Cleveland Clinic Foundation Learner Research Institute, Cleveland, OH
Biswas Abstract (PDF)

Platelet Dream Plays A Critical Role During Thrombogenesis In Mice
Kyungho Kim | University of Illinois at Chicago, Chicago, IL
Kim Abstract (PDF)

WINNER
Genetic Ablation of TMEM16F Exhibits Strain-specific Lethality in Mice
Colin A. Kretz | University of Michigan, Ann Arbor, MI
Kretz Abstract (PDF)

WINNER
Prothrombinase Assembled with Factor V Leiden is Resistant to Inhibition by Tissue Factor Pathway Inhibitor α Lowering the Procoagulant Threshold for Initiation of Coagulation
Jeremy P. Wood | Blood Center of Wisconsin, Milwaukee, WI
Wood Abstract (PDF)

Atherosclerosis Progression is Associated With a Decrease in Pro-Resolving Mediators and Can Be Mitigated with Restoring Resolvin D1
Gabrielle Fredman | Albany Medical College, Albany, NY
Fredman Abstract (PDF)

Sortilin Regulates Arterial Calcification in Atherosclerotic Mice and Associates with Cardiovascular Risk in Humans
Claudia Goettsch | Brigham and Women’s Hospital, Harvard Medical School Boston, MA
Goettsch, Claudia Abstract (PDF)

Bile Acid Synthesis and 12-Hydroxylation are Increased, and Bile Acid Transport is Impaired in Human Obesity
Rebecca Haeusler | Columbia University , New York, NY
Haeusler Abstract (PDF)

WINNER
Quaking Post-Transcriptionally Promotes Differentiation of Monocytes into Pro-Atherogenic Macrophages by Controlling pre-mRNA Splicing and Gene Expression
Eric P. van der Veer | Leiden University Medical Center, Leiden, Netherlands
van der Veer Abstract (PDF)

Clinical and Hemodynamic Insight into the Mechanisms of Initiation of Venous Thrombosis
Fedor Lurie, MD, PHD | Jobst Vascular Institute, Toledo, OH
Lurie Presentation Slides (PDF) | Lurie Video Interview (opens in new window)

Administration of Gut Bacteria Expressing N-acyl Phosphatidylethanolamine Reduces Steatohepatitis In LDLR-/- Mice Fed a Western Diet
Linda S. Zhang | Vanderbilt University, Nashville, TN
Zhang Abstract (PDF)

Network-based Identification and Prioritization of Key Regulators of Coronary Artery Disease Loci
Yuqi Zhao | UCLA, Los Angeles, CA
Zhao Abstract (PDF)

Shear Stress Maintains Endocardial Phenotype In Ipsc Derived Endocardial Cells
Mark Vander Roest | Vanderbilt University, Nashville, TN
Roest Abstract (PDF)

Identification of CHROME as a Competing Endogenous RNA that Regulates Cholesterol Homeostasis
Coen van Solingen | NYU School of Medicine, New York, NY
Solingen Abstract (PDF)

Transcription Coactivator MED1 Protects Against Atherosclerosis by Modulation of Macrophage Polarization
Enqi Liu | Xi'an Jiaotong University, Xi'an, China
Liu Abstract (PDF)

Saturday, May 7

Jeffrey M. Hoeg Award Lecture


Kathryn Moore, PhD, chair of the council on ATVB, interviews Esther Lutgens, MD, PhD about her research on the role of immune checkpoint regulators in atherosclerosis.

Distinguished Lecture


Josh Beckman, MD, chair of the council on Peripheral Vascular Disease, interviews Distinguished Lecturer Garret FitzGerald, MD about his research on the role of molecular clocks in cardiometabolic disease.

Immune Checkpoint Regulators in Atherosclerosis
Esther Lutgens, MD, PhD | University of Amsterdam, Amsterdam, Netherlands
Esther Lutgens Presentation Slides (PDF)  |  Esther Lutgens Video Interview (opens in new window)
Distinguished Lecture on Molecular Clocks and Cardiometabolic Disease
Garret A. FitzGerald, MD, FAHA | University of Pennsylvania, Philadelphia, PA
Garret FitzGerald Presentation Slides (PDF)  |  Garret FitzGerald Video Interview (opens in new window)

Effect of High-intensity Statin Therapy on High-density Lipoprotein (HDL) Subfractions and Regression of Coronary Atheroma: The SATURN Trial
Ron C Hoogeveen | Baylor College of Medicine, Houston, TX
Hoogeveen Abstract (PDF)

Loss of SPRR3 In ApoE-/- Mice Leads to Increased theroma Vulnerability and Evidence of Plaque Rupture and Cardiac Infarcts
Caressa D Lietman | Vanderbilt University Medical Center, Nashville, TN
Lietman Abstract (PDF)

Unraveling the Controversy of Bisphosphonates as Vascular Calcification Therapy Using a Nanoanalytical Approach
Jessica L Ruiz | Brigham and Women's Hospital, Boston, MA
Ruiz Abstract (PDF)

Ineffective Suppression of Adipocyte Lipolysis in Metabolic Syndrome: An in vivo Test for Adipocyte Insulin Resistance
Jennifer Lynn Ford | The Pennsylvania State University, University Park, PA
Ford Abstract (PDF)

Induction of Cardiovascular Calcification in Non-transgenic Mice via a Single Injection of Pcsk9 Adeno-associated Viral Vector
Claudia Goettsch | Brigham and Women's Hospital, Harvard Medical School, Boston, MA
Claudia Goettsch Abstract (PDF)

Modification of HDL by γ-Ketoaldehydes Causes impaired HDL Function in Familial Hypercholesterolemia
Huan Tao | Vanderbilt University School of Medicine, Nashville, TN
Tao Abstract (PDF)

Other Resources

Genome Editing with CRISPR-Cas9

Please watch this video if you are signed up for Bootcamp I.

RNA Sequencing

Please watch this video if you are signed up for Bootcamp II.