SCIENCE NEWS provides an in-depth look at selected ground-breaking studies presented at ATVB|PVD 2016 in Nashville, Tenn. through exclusive video interviews, presentation slides, and more. Keep checking back throughout the conference for the latest information.
Thursday, May 5
Welcome to ATVB|PVD 2016
Mark Creager, MD, president of the American Heart Association, interviews Philip Tsao, PhD and Nancy Webb, PhD, the conference chair and co-chair of ATVB|PVD 2016 about what they have planned for the meeting this year.
A Decade of GWAS Studies in Cardiovascular Disease
Philip Tsao, PhD, conference chair of ATVB PVD 2016, interviews Erik Ingelsson, MD, PhD about his plenary presentation, "Ten Years and Hundreds of Novel Cardiovascular Loci: What Now?"
Developing Novel Therapies for Abdominal Aortic Aneurysm
Nancy Webb, PhD, vice chair for ATVB/PVD 2016, interviews Christine Pham, MD and John Curci, MD about current laboratory and clinical efforts to develop novel therapies for AAA.
Chinese American Academy of Cardiology at ATVB|PVD 2016
Steve Lentz, MD, PhD, vice chair of the council on ATVB, interview Hong Wang, MD, PhD, president of the Chinese American Academy of Cardiology and Eugene, Chen, MD, PhD and Ming-Hui Zou, MD, PhD, chairs of the Metabolic Vascular Disease Symposium about the organization.
The RNA-Binding Protein ADAR2 Controls Interleukin-6-induced Endothelial Cell Proinflammatory Response By Regulating MicroRNA Biogenesis Konstantinos Stellos | J.W. Goethe University, Frankfurt, Frankfurt am Main, Germany Stellos Abstract (PDF)
APOC3 A43T Variant Promotes ApoC-III Catabolism and Accelerates TG-rich Lipoprotein Clearance in Mice and Humans Sumeet A. Khetarpal | University of Pennsylvania, Philadelphia, PA Khetarpal Abstract (PDF)
Nogo-B Controls Inflammation by Regulating Autophagy in Macrophage Jun Yu | Yale University School of Medicine, New Haven, CT Yu Abstract (PDF)
A Natural Repertoire of T Cells 21 Recognizing ApoB-100 is Generated Early in Life and is Progressively Depleted During Atherosclerotic Disease Dennis Wolf | La Jolla Institute for Allergy and Immunology, San Diego, CA Wolf Abstract (PDF)
Inflammatory Responses in Abdominal Aortic Aneurysm: Emerging Targets for Therapy? Christine T.N. Pham, MD | Washington University School of Medicine, St. Louis, MO Pham Presentation Slides (PDF)
The Unique Challenges of Developing Novel Therapies for Abdominal Aortic Aneurysms John A. Curci, MD, FACS |Vanderbilt University Medical Center, Nashville, TN Curci Presentation Slides (PDF)
Statins Have a Dose-dependent Effect on Amputation Risk and Survival in Peripheral Arterial Disease (PAD) Patients Shipra Arya | Emory University, Atlanta, GA Arya Abstract (PDF)
Association of the Serum Myeloperoxidase/High-Density Lipoprotein Particle Ratio and Incident Cardiovascular Events in a Multi-Ethnic Population: Observations From the Dallas Heart Study Htet W Khine | UT Southwestern Medical Center, Dallas, TX Khine Abstract (PDF)
MiR-1200 Differentially Modulates Plasma LDL and HDL cholesterol Levels to Reduce Hyperlipidemia and Atherosclerosis in Mice Liye Zhou | SUNY Downstate Medical Center, Brooklyn, NY Zhou Abstract (PDF)
Friday, May 6
Turning Discovery into Health
Mark Creager, MD, president of the American Heart Association, interviews Zorina Galis, PhD and Marc Charette, PhD of the National Heart, Lung, and Blood Institute about new initiatives for facilitating the translation of scientific discovery into new clinical treatments for improving patient health.
Towards a Better Understanding of Venous Thrombosis
Joshua A. Beckman, MD, MS, chair of the council on PVD, interview Fedor Lurie, MD, PhD about his presentation on the need to better understand the mechanisms contributing to venous thrombosis.
Next Generation Technology Bootcamps 1 & 2
Kiran Musunuru, MD, PhD, MPH and Jane Ferguson, PhD discuss how the Next Generation Technology Bootcamps on genome editing are growing at ATVB|PVD.
Kenneth M. Brinkhous Young Investigator Prize in Thrombosis Finalists
From L-R: Colin A. Kretz, Sudipta Biswas, Kyungho Kim, Jeremy P. Wood, Joseph Italiano, PhD, chair of the Brinkhous Prize Committee
Irvine H. Page Young Award Investigator Research Award Finalists
From L-R: Gabrielle Fredman, Claudia Goettsch,Rebecca Haeusler, Eric P. van der Veer, Jonathan Smith, vice chair of the Page Award Committee
Prothrombotic Role of Platelet Tlr2 40 in Hyperlipidemia Sudipta Biswas | Cleveland Clinic Foundation Learner Research Institute, Cleveland, OH Biswas Abstract (PDF)
Platelet Dream Plays A Critical Role During Thrombogenesis In Mice Kyungho Kim | University of Illinois at Chicago, Chicago, IL Kim Abstract (PDF)
WINNER Genetic Ablation of TMEM16F Exhibits Strain-specific Lethality in Mice Colin A. Kretz | University of Michigan, Ann Arbor, MI Kretz Abstract (PDF)
WINNER Prothrombinase Assembled with Factor V Leiden is Resistant to Inhibition by Tissue Factor Pathway Inhibitor α Lowering the Procoagulant Threshold for Initiation of Coagulation Jeremy P. Wood | Blood Center of Wisconsin, Milwaukee, WI Wood Abstract (PDF)
Atherosclerosis Progression is Associated With a Decrease in Pro-Resolving Mediators and Can Be Mitigated with Restoring Resolvin D1 Gabrielle Fredman | Albany Medical College, Albany, NY Fredman Abstract (PDF)
Sortilin Regulates Arterial Calcification in Atherosclerotic Mice and Associates with Cardiovascular Risk in Humans Claudia Goettsch | Brigham and Women’s Hospital, Harvard Medical School Boston, MA Goettsch, Claudia Abstract (PDF)
Bile Acid Synthesis and 12-Hydroxylation are Increased, and Bile Acid Transport is Impaired in Human Obesity Rebecca Haeusler | Columbia University , New York, NY Haeusler Abstract (PDF)
WINNER Quaking Post-Transcriptionally Promotes Differentiation of Monocytes into Pro-Atherogenic Macrophages by Controlling pre-mRNA Splicing and Gene Expression Eric P. van der Veer | Leiden University Medical Center, Leiden, Netherlands van der Veer Abstract (PDF)
Administration of Gut Bacteria Expressing N-acyl Phosphatidylethanolamine Reduces Steatohepatitis In LDLR-/- Mice Fed a Western Diet Linda S. Zhang | Vanderbilt University, Nashville, TN Zhang Abstract (PDF)
Network-based Identification and Prioritization of Key Regulators of Coronary Artery Disease Loci Yuqi Zhao | UCLA, Los Angeles, CA Zhao Abstract (PDF)
Identification of CHROME as a Competing Endogenous RNA that Regulates Cholesterol Homeostasis Coen van Solingen | NYU School of Medicine, New York, NY Solingen Abstract (PDF)
Transcription Coactivator MED1 Protects Against Atherosclerosis by Modulation of Macrophage Polarization Enqi Liu | Xi'an Jiaotong University, Xi'an, China Liu Abstract (PDF)
Saturday, May 7
Jeffrey M. Hoeg Award Lecture
Kathryn Moore, PhD, chair of the council on ATVB, interviews Esther Lutgens, MD, PhD about her research on the role of immune checkpoint regulators in atherosclerosis.
Josh Beckman, MD, chair of the council on Peripheral Vascular Disease, interviews Distinguished Lecturer Garret FitzGerald, MD about his research on the role of molecular clocks in cardiometabolic disease.
Effect of High-intensity Statin Therapy on High-density Lipoprotein (HDL) Subfractions and Regression of Coronary Atheroma: The SATURN Trial Ron C Hoogeveen | Baylor College of Medicine, Houston, TX Hoogeveen Abstract (PDF)
Loss of SPRR3 In ApoE-/- Mice Leads to Increased theroma Vulnerability and Evidence of Plaque Rupture and Cardiac Infarcts Caressa D Lietman | Vanderbilt University Medical Center, Nashville, TN Lietman Abstract (PDF)
Unraveling the Controversy of Bisphosphonates as Vascular Calcification Therapy Using a Nanoanalytical Approach Jessica L Ruiz | Brigham and Women's Hospital, Boston, MA Ruiz Abstract (PDF)
Ineffective Suppression of Adipocyte Lipolysis in Metabolic Syndrome: An in vivo Test for Adipocyte Insulin Resistance Jennifer Lynn Ford | The Pennsylvania State University, University Park, PA Ford Abstract (PDF)
Induction of Cardiovascular Calcification in Non-transgenic Mice via a Single Injection of Pcsk9 Adeno-associated Viral Vector Claudia Goettsch | Brigham and Women's Hospital, Harvard Medical School, Boston, MA Claudia Goettsch Abstract (PDF)
Modification of HDL by γ-Ketoaldehydes Causes impaired HDL Function in Familial Hypercholesterolemia Huan Tao | Vanderbilt University School of Medicine, Nashville, TN Tao Abstract (PDF)
Genome Editing with CRISPR-Cas9
Please watch this video if you are signed up for Bootcamp I.
Please watch this video if you are signed up for Bootcamp II.